dc.contributor.author
Schwickert, Alexander
dc.contributor.author
Chantraine, Frédéric
dc.contributor.author
Ehrlich, Loreen
dc.contributor.author
Henrich, Wolfgang
dc.contributor.author
Muallem, Mustafa Zelal
dc.contributor.author
Nonnenmacher, Andreas
dc.contributor.author
Petit, Philippe
dc.contributor.author
Weizsäcker, Katharina
dc.contributor.author
Braun, Thorsten
dc.date.accessioned
2022-09-21T07:52:47Z
dc.date.available
2022-09-21T07:52:47Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36398
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-36114
dc.description.abstract
The aim of this study was to test if maternal serum vascular endothelial growth factor (VEGF) or N-terminal pro B-type natriuretic peptide (NT-proBNP) predicts abnormally invasive placenta (AIP) better. Secondary objective was to test whether the serum levels of VEGF and NT-proBNP can predict the degree of invasion. In a multicenter case–control study design, gestational age-matched serum samples from pregnant women with AIP (n = 44) and uncomplicated pregnancies (n = 55) who had been enrolled at Charité – Universitätsmedizin Berlin, Germany and Centre Hospitalier Régional de la Citadelle in Liège, Belgium were analyzed. Maternal blood serum VEGF and NT-proBNP levels were immunoassayed from samples taken immediately before delivery (GA median: 35 weeks). Biomarker levels were compared between AIP and control group. The correlation of biomarker levels with the clinical AIP degree was assessed. The predictive biomarker ability was characterized through a multivariate regression model and receiver operating characteristic curves. Women with AIP had significantly lower maternal serum VEGF levels (AIP mean 285 pg/ml, 95% CI 248–322, vs. control: 391 pg/ml, 95% CI 356–426, p < 0.01) and higher NT-proBNP levels (AIP median 329 pg/ml, IQR 287–385, vs. control 295 pg/ml, IQR 273–356, p = 0.03). Maternal serum VEGF levels were able to predict AIP better (AUC = 0.729, 0.622–0.836, p < 0.001; VEGF + number of previous cesarean deliveries: AUC = 0.915, 0.853–0.977, p < 0.001). Maternal serum VEGF levels correlated inversely with the clinical AIP degree (r = − 0.32, p < 0.01). In short, maternal serum VEGF, more than NT-proBNP, can help in predicting AIP and hints at the degree of invasion.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Vascular endothelial growth factor
en
dc.subject
Placenta increta
en
dc.subject
Placenta percreta
en
dc.subject
Abnormally invasive placenta
en
dc.subject
Placenta accreta spectrum
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Maternal Serum VEGF Predicts Abnormally Invasive Placenta Better than NT-proBNP: a Multicenter Case-Control Study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1007/s43032-020-00319-y
dcterms.bibliographicCitation.journaltitle
Reproductive Sciences
dcterms.bibliographicCitation.originalpublishername
Springer Nature
dcterms.bibliographicCitation.pagestart
361
dcterms.bibliographicCitation.pageend
370
dcterms.bibliographicCitation.volume
28
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
Springer Nature DEAL
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33025531
dcterms.isPartOf.issn
1933-7191
dcterms.isPartOf.eissn
1933-7205