dc.contributor.author
Appunni, Sandeep
dc.contributor.author
Rubens, Muni
dc.contributor.author
Ramamoorthy, Venkataraghavan
dc.contributor.author
Saxena, Anshul
dc.contributor.author
McGranaghan, Peter
dc.contributor.author
Veledar, Emir
dc.date.accessioned
2022-09-05T13:01:15Z
dc.date.available
2022-09-05T13:01:15Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36183
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35899
dc.description.abstract
The pathophysiology of stoke involves many complex pathways and risk factors. Though there are several ongoing studies on stroke, treatment options are limited, and the prevalence of stroke is continuing to increase. Understanding the genomic variants and biological pathways associated with stroke could offer novel therapeutic alternatives in terms of drug targets and receptor modulations for newer treatment methods. It is challenging to identify individual causative mutations in a single gene because many alleles are responsible for minor effects. Therefore, multiple factorial analyses using single nucleotide polymorphisms (SNPs) could be used to gain new insight by identifying potential genetic risk factors. There are many studies, such as Genome-Wide Association Studies (GWAS) and Phenome-Wide Association Studies (PheWAS) which have identified numerous independent loci associated with stroke, which could be instrumental in developing newer drug targets and novel therapies. Additionally, using analytical techniques, such as meta-analysis and Mendelian randomization could help in evaluating stroke risk factors and determining treatment priorities. Combining SNPs into polygenic risk scores and lifestyle risk factors could detect stroke risk at a very young age and help in administering preventive interventions.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Mendelian inheritance
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Stroke Genomics: Current Knowledge, Clinical Applications and Future Possibilities
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
302
dcterms.bibliographicCitation.doi
10.3390/brainsci12030302
dcterms.bibliographicCitation.journaltitle
Brain Sciences
dcterms.bibliographicCitation.number
3
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35326259
dcterms.isPartOf.eissn
2076-3425