dc.contributor.author
Basso, Laura
dc.contributor.author
Boecking, Benjamin
dc.contributor.author
Neff, Patrick
dc.contributor.author
Brueggemann, Petra
dc.contributor.author
Mazurek, Birgit
dc.contributor.author
Peters, Eva M. J.
dc.date.accessioned
2022-08-30T09:02:17Z
dc.date.available
2022-08-30T09:02:17Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/36069
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-35785
dc.description.abstract
Background: Currently, there are no objective markers to measure treatment efficacy in chronic (distressing) tinnitus. This study explores whether stress-related biomarkers cortisol and brain-derived neurotrophic factor (BDNF) measured in hair samples of chronic tinnitus patients change after compact multimodal tinnitus-specific cognitive behavioral therapy.
Methods: In this longitudinal study, hair-cortisol and hair-BDNF levels, self-reported tinnitus-related distress (Tinnitus Questionnaire; TQ), and perceived stress (Perceived Stress Questionnaire; PSQ-20) were assessed before and 3 months after 5 days of treatment in N = 80 chronic tinnitus patients. Linear mixed-effects models with backward elimination were used to assess treatment-induced changes, and a cross-lagged panel model (structural equation model) was used for additional exploratory analysis of the temporal associations between TQ and hair-BDNF.
Results: At follow-up, a reduction in TQ (p < 0.001) and PSQ-20 scores (p = 0.045) was observed, which was not influenced by baseline hair-cortisol or hair-BDNF levels. No changes in biomarker levels were observed after treatment. The exploratory analysis tentatively suggests that a directional effect of baseline TQ scores on hair-BDNF levels at follow-up (trend; p = 0.070) was more likely than the opposite directional effect of baseline hair-BDNF levels on TQ scores at follow-up (n.s.).
Discussion: While the treatment effectively reduced tinnitus-related distress and perceived stress in chronic tinnitus patients, this effect was not mirrored in biological changes. However, the lack of changes in hair-cortisol and hair-BDNF levels might have been influenced by the treatment duration, follow-up interval, or confounding medical factors, and therefore must be interpreted with caution. The relationship between tinnitus-related distress and hair-BDNF levels should be explored further to obtain a better understanding of stress-related effects in chronic tinnitus.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
chronic tinnitus
en
dc.subject
cognitive behavioral therapy (CBT)
en
dc.subject
brain-derived neurotrophic factor (BDNF)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Psychological Treatment Effects Unrelated to Hair-Cortisol and Hair-BDNF Levels in Chronic Tinnitus
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
764368
dcterms.bibliographicCitation.doi
10.3389/fpsyt.2022.764368
dcterms.bibliographicCitation.journaltitle
Frontiers in Psychiatry
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
13
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
35250657
dcterms.isPartOf.eissn
1664-0640