dc.contributor.author
Lipp, Theresa
dc.contributor.author
Acar Şahin, Aydan
dc.contributor.author
Aggelidis, Xenophon
dc.contributor.author
Arasi, Stefania
dc.contributor.author
Barbalace, Andrea
dc.contributor.author
Bourgoin, Anne
dc.contributor.author
Bregu, Blerina
dc.contributor.author
Brighetti, Maria Antonia
dc.contributor.author
Caeiro, Elsa
dc.contributor.author
Caglayan Sozmen, Sule
dc.contributor.author
Caminiti, Lucia
dc.contributor.author
Charpin, Denis
dc.contributor.author
Couto, Mariana
dc.contributor.author
Delgado, Luís
dc.contributor.author
Di Rienzo Businco, Andrea
dc.contributor.author
Dimier, Claire
dc.contributor.author
Dimou, Maria V.
dc.contributor.author
Fonseca, João A.
dc.contributor.author
Goksel, Ozlem
dc.contributor.author
Guvensen, Aykut
dc.contributor.author
Hernandez, Dolores
dc.contributor.author
Hoffmann, Tara Maria
dc.contributor.author
Jang, Dah Tay
dc.contributor.author
Kalpaklioglu, Fusun
dc.contributor.author
Lame, Blerta
dc.contributor.author
Llusar, Ruth
dc.contributor.author
Makris, Michael P.
dc.contributor.author
Mazon, Angel
dc.contributor.author
Mesonjesi, Eris
dc.contributor.author
Nieto, Antonio
dc.contributor.author
Öztürk, Ayse
dc.contributor.author
Pahus, Laurie
dc.contributor.author
Pajno, Giovanni Battista
dc.contributor.author
Panasiti, Ilenia
dc.contributor.author
Papadopoulos, Nikolaos G.
dc.contributor.author
Pellegrini, Elisabetta
dc.contributor.author
Pelosi, Simone
dc.contributor.author
Pereira, Ana M.
dc.contributor.author
Pereira, Mariana
dc.contributor.author
Pinar, Munevver
dc.contributor.author
Potapova, Ekaterina
dc.contributor.author
Priftanji, Alfred
dc.contributor.author
Psarros, Fotis
dc.contributor.author
Sackesen, Cansin
dc.contributor.author
Sfika, Ifigenia
dc.contributor.author
Suarez, Javier
dc.contributor.author
Thibaudon, Michel
dc.contributor.author
Travaglini, Alessandro
dc.contributor.author
Tripodi, Salvatore
dc.contributor.author
Verdier, Valentine
dc.contributor.author
Villella, Valeria
dc.contributor.author
Xepapadaki, Paraskevi
dc.contributor.author
Yazici, Duygu
dc.contributor.author
Matricardi, Paolo M.
dc.contributor.author
Dramburg, Stephanie
dc.date.accessioned
2022-03-14T14:21:09Z
dc.date.available
2022-03-14T14:21:09Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34387
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34105
dc.description.abstract
Background Pollen food allergy syndrome (PFAS) is a frequently underdiagnosed disease due to diverse triggers, clinical presentations, and test results. This is especially relevant in geographic areas with a broad spectrum of pollen sensitization, such as Southern Europe. Objectives To elucidate similarities and differences of PFAS in nine Southern European centers and identify associated characteristics and unique markers of PFAS. Methods As part of the @IT.2020 Multicenter Study, 815 patients with seasonal allergic rhinitis (SAR), aged 10-60 years, were recruited in seven countries. They completed questionnaires regarding SAR, comorbidities, family history, and PFAS, and underwent skin prick testing (SPT) and serum IgE testing. Results Of the 815 patients, 167 (20.5%) reported PFAS reactions. Most commonly, eliciting foods were kiwi (58, 34.7%), peach (43, 25.7%), and melon (26, 15.6%). Reported reactions were mostly local (216/319, 67.7%), occurring within 5 min of contact with elicitors (209/319, 65.5%). Associated characteristics included positive IgE to at least one panallergen (profilin, PR-10, or nsLTP) (p = 0.007), maternal PFAS (OR: 3.716, p = 0.026), and asthma (OR: 1.752, p = 0.073). Between centers, heterogeneity in prevalence (Marseille: 7.5% vs. Rome: 41.4%, p < 0.001) and of clinical characteristics was apparent. Cypress played a limited role, with only 1/22 SPT mono-sensitized patients reporting a food reaction (p < 0.073). Conclusions PFAS is a frequent comorbidity in Southern European SAR patients. Significant heterogeneity of clinical characteristics in PFAS patients among the centers was observed and may be related to the different pollen sensitization patterns in each geographic area. IgE to panallergen(s), maternal PFAS, and asthma could be PFAS-associated characteristics.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
oral allergy syndrome
en
dc.subject
pollen food allergy syndrome
en
dc.subject
seasonal allergic rhinitis
en
dc.subject
Southern Europe
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1111/all.14742
dcterms.bibliographicCitation.journaltitle
Allergy
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
3041
dcterms.bibliographicCitation.pageend
3052
dcterms.bibliographicCitation.volume
76
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33492738
dcterms.isPartOf.issn
0105-4538
dcterms.isPartOf.eissn
1398-9995