dc.contributor.author
Mainka, Tina
dc.contributor.author
Balint, Bettina
dc.contributor.author
Gövert, Felix
dc.contributor.author
Kurvits, Lille
dc.contributor.author
Riesen, Christoph van
dc.contributor.author
Kühn, Andrea A.
dc.contributor.author
Tijssen, Marina A. J.
dc.contributor.author
Lees, Andrew J.
dc.contributor.author
Müller‐Vahl, Kirsten
dc.contributor.author
Bhatia, Kailash P.
dc.contributor.author
Ganos, Christos
dc.date.accessioned
2022-03-03T14:27:51Z
dc.date.available
2022-03-03T14:27:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34319
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34036
dc.description.abstract
In clinical practice, involuntary vocalizing behaviors are typically associated with Tourette syndrome and other tic disorders. However, they may also be encountered throughout the entire tenor of neuropsychiatry, movement disorders, and neurodevelopmental syndromes. Importantly, involuntary vocalizing behaviors may often constitute a predominant clinical sign, and, therefore, their early recognition and appropriate classification are necessary to guide diagnosis and treatment. Clinical literature and video-documented cases on the topic are surprisingly scarce. Here, we pooled data from 5 expert centers of movement disorders, with instructive video material to cover the entire range of involuntary vocalizations in humans. Medical literature was also reviewed to document the range of possible etiologies associated with the different types of vocalizing behaviors and to explore treatment options. We propose a phenomenological classification of involuntary vocalizations within different categorical domains, including (1) tics and tic-like vocalizations, (2) vocalizations as part of stereotypies, (3) vocalizations as part of dystonia or chorea, (4) continuous vocalizing behaviors such as groaning or grunting, (5) pathological laughter and crying, (6) vocalizations resembling physiological reflexes, and (7) other vocalizations, for example, those associated with exaggerated startle responses, as part of epilepsy and sleep-related phenomena. We provide comprehensive lists of their associated etiologies, including neurodevelopmental, neurodegenerative, neuroimmunological, and structural causes and clinical clues. We then expand on the pathophysiology of the different vocalizing behaviors and comment on available treatment options. Finally, we present an algorithmic approach that covers the wide range of involuntary vocalizations in humans, with the ultimate goal of improving diagnostic accuracy and guiding appropriate treatment.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
involuntary vocalizations
en
dc.subject
movement disorders
en
dc.subject
vocalizing behavior
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The spectrum of involuntary vocalizations in humans: A video atlas
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/mds.27855
dcterms.bibliographicCitation.journaltitle
Movement Disorders
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
1774
dcterms.bibliographicCitation.pageend
1791
dcterms.bibliographicCitation.volume
34
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31651053
dcterms.isPartOf.issn
0885-3185
dcterms.isPartOf.eissn
1531-8257