dc.contributor.author
Wu, Hao
dc.contributor.author
Reimann, Sabine
dc.contributor.author
Siddiqui, Sophiya
dc.contributor.author
Haag, Rainer
dc.contributor.author
Siegmund, Britta
dc.contributor.author
Dernedde, Jens
dc.contributor.author
Glauben, Rainer
dc.date.accessioned
2022-03-03T10:37:37Z
dc.date.available
2022-03-03T10:37:37Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34311
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-34028
dc.description.abstract
The synthetic compound dendritic polyglycerol sulfate (dPGS) is a pleiotropic acting molecule but shows a high binding affinity to immunological active molecules as L-/P-selectin or complement proteins leading to well described anti-inflammatory properties in various mouse models. In order to make a comprehensive evaluation of the direct effect on the innate immune system, macrophage polarization is analyzed in the presence of dPGS on a phenotypic but also metabolic level. dPGS administered macrophages show a significant increase of MCP1 production paralleled by a reduction of IL-10 secretion. Metabolic analysis reveals that dPGS could potently enhance the glycolysis and mitochondrial respiration in M0 macrophages as well as decrease the mitochondrial respiration of M2 macrophages. In summary the data indicate that dPGS polarizes macrophages into a pro-inflammatory phenotype in a metabolic pathway-dependent manner.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
macrophage polarization
en
dc.subject
metabolic switch
en
dc.subject
polyglycerol sulfates
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
dPGS Regulates the Phenotype of Macrophages via Metabolic Switching
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1900184
dcterms.bibliographicCitation.doi
10.1002/mabi.201900184
dcterms.bibliographicCitation.journaltitle
Macromolecular Bioscience
dcterms.bibliographicCitation.number
12
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
19
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31631571
dcterms.isPartOf.issn
1616-5187
dcterms.isPartOf.eissn
1616-5195