dc.contributor.author
Nie, Chuanxiong
dc.contributor.author
Sahoo, Anil Kumar
dc.contributor.author
Netz, Roland R.
dc.contributor.author
Herrmann, Andreas
dc.contributor.author
Ballauff, Matthias
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2022-03-21T12:05:59Z
dc.date.available
2022-03-21T12:05:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34173
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33891
dc.description.abstract
Evidence is strengthening to suggest that the novel SARS-CoV-2 mutant Omicron, with its more than 60 mutations, will spread and dominate worldwide. Although the mutations in the spike protein are known, the molecular basis for why the additional mutations in the spike protein that have not previously occurred account for Omicron's higher infection potential, is not understood. We propose, based on chemical rational and molecular dynamics simulations, that the elevated occurrence of positively charged amino acids in certain domains of the spike protein (Delta: +4; Omicron: +5 vs. wild type) increases binding to cellular polyanionic receptors, such as heparan sulfate due to multivalent charge-charge interactions. This observation is a starting point for targeted drug development.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
Charge Matters: Mutations in Omicron Variant Favor Binding to Cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e202100681
dcterms.bibliographicCitation.doi
10.1002/cbic.202100681
dcterms.bibliographicCitation.journaltitle
ChemBioChem
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.volume
23
dcterms.bibliographicCitation.url
https://doi.org/10.1002/cbic.202100681
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation
Physik
refubium.affiliation.other
Institut für Chemie und Biochemie

refubium.funding
DEAL Wiley
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1439-7633
refubium.resourceType.provider
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