dc.contributor.author
Finger, Anna‐Marie
dc.contributor.author
Dibner, Charna
dc.contributor.author
Kramer, Achim
dc.date.accessioned
2022-02-16T14:03:29Z
dc.date.available
2022-02-16T14:03:29Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/34027
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33745
dc.description.abstract
The circadian system is composed of coupled endogenous oscillators that allow living beings, including humans, to anticipate and adapt to daily changes in their environment. In mammals, circadian clocks form a hierarchically organized network with a 'master clock' located in the suprachiasmatic nucleus of the hypothalamus, which ensures entrainment of subsidiary oscillators to environmental cycles. Robust rhythmicity of body clocks is indispensable for temporally coordinating organ functions, and the disruption or misalignment of circadian rhythms caused for instance by modern lifestyle is strongly associated with various widespread diseases. This review aims to provide a comprehensive overview of our current knowledge about the molecular architecture and system-level organization of mammalian circadian oscillators. Furthermore, we discuss the regulatory roles of peripheral clocks for cell and organ physiology and their implication in the temporal coordination of metabolism in human health and disease. Finally, we summarize methods for assessing circadian rhythmicity in humans.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
circadian disruption
en
dc.subject
circadian misalignment
en
dc.subject
human circadian system
en
dc.subject
intercellular coupling
en
dc.subject
metabolic diseases
en
dc.subject
peripheral clocks
en
dc.subject
physiology and metabolism
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Coupled network of the circadian clocks: a driving force of rhythmic physiology
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/1873-3468.13898
dcterms.bibliographicCitation.journaltitle
FEBS Letters
dcterms.bibliographicCitation.number
17
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.pagestart
2734
dcterms.bibliographicCitation.pageend
2769
dcterms.bibliographicCitation.volume
594
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32750151
dcterms.isPartOf.issn
0014-5793
dcterms.isPartOf.eissn
1873-3468