dc.contributor.author
Fuest, Kristina. E.
dc.contributor.author
Lorenz, Marco
dc.contributor.author
Grunow, Julius J.
dc.contributor.author
Weiss, Björn
dc.contributor.author
Mörgeli, Rudolf
dc.contributor.author
Finkenzeller, Sebastian
dc.contributor.author
Bogdanski, Ralph
dc.contributor.author
Heim, Markus
dc.contributor.author
Kapfer, Barbara
dc.contributor.author
Kriescher, Silja
dc.contributor.author
Lingg, Charlotte
dc.contributor.author
Martin, Jan
dc.contributor.author
Ulm, Bernhard
dc.contributor.author
Jungwirth, Bettina
dc.contributor.author
Blobner, Manfred
dc.contributor.author
Schaller, Stefan J.
dc.date.accessioned
2022-01-21T10:14:51Z
dc.date.available
2022-01-21T10:14:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/33678
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-33398
dc.description.abstract
Background: Long-term outcome is determined not only by the acute critical illness but increasingly by the reduced functional reserve of pre-existing frailty. The patients with frailty currently account for one-third of the critically ill, resulting in higher mortality. There is evidence of how frailty affects the intrahospital functional trajectory of critically ill patients since prehospital status is often missing.
Methods: In this prospective single-center cohort study at two interdisciplinary intensive care units (ICUs) at a university hospital in Germany, the frailty was assessed using the Clinical Frailty Scale (CFS) in the adult patients with critical illness with an ICU stay >24 h. The functional status was assessed using the sum of the subdomains "Mobility" and "Transfer" of the Barthel Index (MTB) at three time points (pre-hospital, ICU discharge, and hospital discharge).
Results: We included 1,172 patients with a median age of 75 years, of which 290 patients (25%) were frail. In a propensity score-matched cohort, the probability of MTB deterioration till hospital discharge did not differ in the patients with frailty (odds ratio (OR) 1.3 [95% CI 0.8-1.9], p = 0.301), confirmed in several sensitivity analyses in all the patients and survivors only.
Conclusion: The patients with frailty have a reduced functional status. Their intrahospital functional trajectory, however, was not worse than those in non-frail patients, suggesting a rehabilitation potential of function in critically ill patients with frailty.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
critical illness
en
dc.subject
outcome assessment
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The Functional Trajectory in Frail Compared With Non-frail Critically Ill Patients During the Hospital Stay
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
748812
dcterms.bibliographicCitation.doi
10.3389/fmed.2021.748812
dcterms.bibliographicCitation.journaltitle
Frontiers in Medicine
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34805218
dcterms.isPartOf.eissn
2296-858X