Title:
Shear Wave Elastography in the Detection of Sinusoidal Obstruction Syndrome in Adult Patients Undergoing Allogenic Hematopoietic Stem Cell Transplantation
Author(s):
Schulz, Marten; Vuong, Lam Giang; Müller, Hans Peter; Maibier, Martin; Tacke, Frank; Blau, Igor Wolfgang; Wree, Alexander
Year of publication:
2021
Available Date:
2021-11-09T12:29:06Z
Abstract:
Hepatic sinusoidal obstruction syndrome (SOS), also known as veno-occlusive disease (VOD) can be a life-threatening complication after hematopoietic stem cell transplantation (HSCT). Diagnosis is often difficult and traditionally based on clinical parameters. Shear wave elastography (SWE) is a modern non-invasive liver stiffness measurement technique using ultrasound. In this monocentric study, we evaluated the role of SWE in diagnosing SOS/VOD in 63 adult patients undergoing HSCT from February 2020 to August 2020 in real world settings. Three patients developed SOS/VOD. This was accompanied by an increase in shear wave velocity in all three patients, indicating that this method may contribute to establishing the diagnosis SOS/VOD after HSCT.
Part of Identifier:
e-ISSN (online): 2075-4418
Keywords:
sinusoidal obstruction syndrome (SOS)
veno-occlusive disease (VOD)
hematopoietic stem cell transplantation (HSCT)
shear wave elastography (SWE)
liver stiffness measurement (LSM)
DDC-Classification:
610 Medizin und Gesundheit
Publication Type:
Wissenschaftlicher Artikel
DOI of the Original Publication:
PubMed ID of the Original Publication:
Journaltitle:
Diagnostics
Department/institution:
Charité - Universitätsmedizin Berlin