dc.contributor.author
Wust, Peter
dc.contributor.author
Stein, Ulrike
dc.contributor.author
Ghadjar, Pirus
dc.date.accessioned
2021-10-15T13:13:09Z
dc.date.available
2021-10-15T13:13:09Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32339
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-32064
dc.description.abstract
The temperature-independent effects of electromagnetic fields (EMF) have been controversial for decades. Here, we critically analyze the available literature on non-thermal effects of radiofrequency (RF) and microwave EMF. We present a literature review of preclinical and clinical data on non-thermal antiproliferative effects of various EMF applications, including conventional RF hyperthermia (HT, cRF-HT). Further, we suggest and evaluate plausible biophysical and electrophysiological models to decipher non-thermal antiproliferative membrane effects. Available preclinical and clinical data provide sufficient evidence for the existence of non-thermal antiproliferative effects of exposure to cRF-HT, and in particular, amplitude modulated (AM)-RF-HT. In our model, transmembrane ion channels function like RF rectifiers and low-pass filters. cRF-HT induces ion fluxes and AM-RF-HT additionally promotes membrane vibrations at specific resonance frequencies, which explains the non-thermal antiproliferative membrane effects via ion disequilibrium (especially of Ca²+) and/or resonances causing membrane depolarization, the opening of certain (especially Ca²+) channels, or even hole formation. AM-RF-HT may be tumor-specific owing to cancer-specific ion channels and because, with increasing malignancy, membrane elasticity parameters may differ from that in normal tissues. Published literature suggests that non-thermal antiproliferative effects of cRF-HT are likely to exist and could present a high potential to improve future treatments in oncology.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Non-thermal effects
en
dc.subject
electromagnetic fields
en
dc.subject
radiofrequency
en
dc.subject
amplitude modulation
en
dc.subject
hyperthermia
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Non-thermal membrane effects of electromagnetic fields and therapeutic applications in oncology
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1080/02656736.2021.1914354
dcterms.bibliographicCitation.journaltitle
International Journal of Hyperthermia
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Taylor & Francis
dcterms.bibliographicCitation.pagestart
715
dcterms.bibliographicCitation.pageend
731
dcterms.bibliographicCitation.volume
38
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33910472
dcterms.isPartOf.eissn
1464-5157