dc.contributor.author
Liang, Wanjun
dc.contributor.author
Bhatia, Sumati
dc.contributor.author
Reisbeck, Felix
dc.contributor.author
Zhong, Yinan
dc.contributor.author
Singh, Abhishek Kumar
dc.contributor.author
Li, Wenzhong
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2021-10-18T10:49:38Z
dc.date.available
2021-10-18T10:49:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32116
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31844
dc.description.abstract
The recently emerging stem-cell artificial niche engineering in induced pluripotent stem cell (iPSCs) 3D cultures has provided enormous opportunities to fully utilize the potential of these cells in biomedical applications. Although a fully chemically defined niche environment can supply cells with desirable safety for clinical use, establishing an artificial degradable niche environment for the controlled release of proliferated cells under mild conditions is still a big challenge. Here, an advanced controlled releasable iPSC 3D artificial niche is reported based on dendritic polyglycerol and poly(N-isopropylacrylamide)-co-polyethylene glycol polymers via a physical–chemical cogelation strategy. Benefiting from the chemically defined synthetic materials and their precise cooperation by covalent cross-linking and physical phase transition, the cogelation-based artificial niche system can be adjusted with optimal parameters and owns high cell biocompatibility to support the robust production of high quality iPSCs with an excellent expansion efficiency. Moreover, the expanded cells can be released out of their niche environment controllably only by adjusting the temperature. Overall, this controlled release hydrogel scaffold shows great promise in iPSC 3D culture for downstream applications.
en
dc.format.extent
16 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc/4.0/
dc.subject
dendritic polyglycerol
en
dc.subject
induced pluripotent stem cells
en
dc.subject
physical–chemical cogelation
en
dc.subject
poly(N-isopropylacrylamide)-co-polyethylene glycol
en
dc.subject
three-dimensional artificial niches
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2010630
dcterms.bibliographicCitation.doi
10.1002/adfm.202010630
dcterms.bibliographicCitation.journaltitle
Advanced Functional Materials
dcterms.bibliographicCitation.number
40
dcterms.bibliographicCitation.volume
31
dcterms.bibliographicCitation.url
https://doi.org/10.1002/adfm.202010630
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
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refubium.funding
DEAL Wiley
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1616-3028
refubium.resourceType.provider
WoS-Alert