dc.contributor.author
Heimesaat, Markus M.
dc.contributor.author
Mousavi, Soraya
dc.contributor.author
Weschka, Dennis
dc.contributor.author
Bereswill, Stefan
dc.date.accessioned
2021-09-30T10:04:25Z
dc.date.available
2021-09-30T10:04:25Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32113
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31841
dc.description.abstract
Human infections with enteropathogenic Campylobacter jejuni (C. jejuni) including multi-drug resistant isolates are emerging worldwide. Antibiotics-independent approaches in the combat of campylobacteriosis are therefore highly desirable. Since the health-beneficial including anti-inflammatory and anti-infectious properties of cardamom have been acknowledged for long, we here addressed potential anti-pathogenic and immune-modulatory effects of this natural compound during acute campylobacteriosis. For this purpose, microbiota-depleted IL-10(-/-) mice were orally infected with C. jejuni strain 81-176 and subjected to cardamom essential oil (EO) via the drinking water starting on day 2 post-infection. Cardamom EO treatment resulted in lower intestinal pathogen loads and improved clinical outcome of mice as early as day 3 post-infection. Furthermore, when compared to mock controls, cardamom EO treated mice displayed less distinct macroscopic and microscopic inflammatory sequelae on day 6 post-infection that were paralleled by lower colonic numbers of macrophages, monocytes, and T cells and diminished pro-inflammatory mediator secretion not only in the intestinal tract, but also in extra-intestinal and, remarkably, systemic organs. In conclusion, our preclinical intervention study provides the first evidence that cardamom EO comprises a promising compound for the combat of acute campylobacteriosis and presumably prevention of post-infectious morbidities.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cardamom essential oil
en
dc.subject
enteropathogenic infection
en
dc.subject
Campylobacter jejuni
en
dc.subject
immune-modulatory effects
en
dc.subject
antipathogenic effects
en
dc.subject
microbiota-depleted IL-10(-/-) mice
en
dc.subject
campylobacteriosis model
en
dc.subject
host-pathogen interaction
en
dc.subject
preclinical intervention study
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Anti-Pathogenic and Immune-Modulatory Effects of Peroral Treatment with Cardamom Essential Oil in Acute Murine Campylobacteriosis
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
169
dcterms.bibliographicCitation.doi
10.3390/microorganisms9010169
dcterms.bibliographicCitation.journaltitle
Microorganisms
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33466708
dcterms.isPartOf.eissn
2076-2607