dc.contributor.author
Ehret, Felix
dc.contributor.author
Kufeld, Markus
dc.contributor.author
Fürweger, Christoph
dc.contributor.author
Haidenberger, Alfred
dc.contributor.author
Windisch, Paul
dc.contributor.author
Senger, Carolin
dc.contributor.author
Kord, Melina
dc.contributor.author
Träger, Malte
dc.contributor.author
Kaul, David
dc.contributor.author
Schichor, Christian
dc.contributor.author
Tonn, Jörg-Christian
dc.contributor.author
Muacevic, Alexander
dc.date.accessioned
2021-09-27T08:21:38Z
dc.date.available
2021-09-27T08:21:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/32057
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31785
dc.description.abstract
Background: Ependymomas are rare neoplasms of the central nervous system (CNS), usually localized intracranially and most commonly diagnosed in children. Spinal ependymomas are more frequent in young adults. They are either primary lesions or manifest as disseminated seeding of cranial tumors. Data on the management of spinal ependymoma lesions remain scarce, especially concerning stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT). The purpose of this study is to report the treatment outcomes of two institutions using robotic radiosurgery (RRS) for the treatment of spinal ependymomas.
Materials and Methods: All patients with a histopathologically confirmed diagnosis of an ependymoma WHO grade II or III who were treated with RRS for one or more spinal lesions were included in this analysis.
Results: Twelve patients underwent RRS for the treatment of 32 spinal ependymoma lesions between 2005 and 2020. Two patients were below the age of 18 when treated, whereas nine patients (75%) suffered from a primary spinal ependymoma. The median dose was 15 Gy prescribed to a median isodose of 70%, with 27 lesions (84%) receiving a single-session treatment. The local control (LC) after a median follow-up of 56.7 months was 84%. LC rates at 1, 3, and 5 years were 92, 85, and 77%, respectively. The Kaplan-Meier estimated overall survival after 1, 3, and 5 years were 75, 75, and 64%, respectively. Five patients died, all of them suffering from an anaplastic ependymoma, with widespread CNS tumor progression being the reason for death in four patients. The majority of patients (58%) showed a stable neurological status at the last available follow-up. Overall, the treatment was well tolerated.
Conclusion: RRS appears to be a safe and efficient treatment modality for managing primary and secondary spinal ependymal tumors in patients with multiple lesions and local recurrences.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
ependymal tumors
en
dc.subject
radiosurgery
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Image-Guided Robotic Radiosurgery for the Management of Spinal Ependymomas
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
654251
dcterms.bibliographicCitation.doi
10.3389/fonc.2021.654251
dcterms.bibliographicCitation.journaltitle
Frontiers in Oncology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33996577
dcterms.isPartOf.eissn
2234-943X