dc.contributor.author
Brandenburg, Susan
dc.contributor.author
Blank, Anne
dc.contributor.author
Bungert, Alexander D.
dc.contributor.author
Vajkoczy, Peter
dc.date.accessioned
2021-09-14T08:57:10Z
dc.date.available
2021-09-14T08:57:10Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31947
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31678
dc.description.abstract
For decades, it has been known that the tumor microenvironment is significant for glioma progression, namely the infiltration of myeloid cells like microglia and macrophages. Hence, these cell types and their specific tasks in tumor progression are subject to ongoing research. However, the distribution of the brain resident microglia and the peripheral macrophages within the tumor tissue and their functional activity are highly debated. Results depend on the method used to discriminate between microglia and macrophages, whereby this specification is already difficult due to limited options to distinguish between these both cell populations that show mostly the same surface markers and morphology. Moreover, there are indications about various functions of microglia and macrophages but again varying on the method of discrimination. In our review, we summarize the current literature to determine which methods have been applied to differentiate the brain resident microglia from tumor-infiltrated macrophages. Furthermore, we compiled data about the proportion of microglia and macrophages in glioma tissues and ascertained if pro- or anti-tumoral effects could be allocated to one or the other myeloid cell population. Recent research made tremendous efforts to distinguish microglia from recruited macrophages. For future studies, it could be essential to verify which role these cells play in brain tumor pathology to proceed with novel immunotherapeutic strategies.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
myeloid cells
en
dc.subject
tumor microenvironment
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Distinction of Microglia and Macrophages in Glioblastoma: Close Relatives, Different Tasks?
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
194
dcterms.bibliographicCitation.doi
10.3390/ijms22010194
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
22
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33375505
dcterms.isPartOf.eissn
1422-0067