dc.contributor.author
Gärtner, Matti
dc.contributor.author
Aust, Sabine
dc.contributor.author
Bajbouj, Malek
dc.contributor.author
Fan, Yan
dc.contributor.author
Wingenfeld, Katja
dc.contributor.author
Otte, Christian
dc.contributor.author
Heuser-Collier, Isabella
dc.contributor.author
Böker, Heinz
dc.contributor.author
Hättenschwiler, Josef
dc.contributor.author
Seifritz, Erich
dc.contributor.author
Grimm, Simone
dc.contributor.author
Scheidegger, Milan
dc.date.accessioned
2021-08-18T12:01:46Z
dc.date.available
2021-08-18T12:01:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31615
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31346
dc.description.abstract
Converging evidence suggests that a single sub-anesthetic dose of ketamine can produce strong and rapid antidepressant effects in patients that do not respond to standard treatment. Despite a considerable amount of research investigating ketamine's mechanisms of action, the exact neuronal targets conveying the antidepressant effects have not been identified yet. Preclinical studies suggest that molecular changes induced by ketamine bring forward large-scale network reconfigurations that might relate to ketamine's antidepressant properties. In this prospective two-site study we measured resting state fMRI in 24 depressed patients prior to, and 24 h after a single sub-anesthetic dose of ketamine. We analyzed functional connectivity (FC) at baseline and after ketamine and focused our analysis on baseline FC and FC changes directly linked to symptom reduction in order to identify neuronal targets that predict individual clinical responses to ketamine. Our results show that FC increases after ketamine between right lateral prefrontal cortex (PFC) and subgenual anterior cingulate cortex (sgACC) are positively linked to treatment response. Furthermore, low baseline FC between these regions predicts treatment outcome. We conclude that PFC-sgACC connectivity may represent a promising biomarker with both predictive and explanatory power.
en
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
Functional connectivity
en
dc.subject
Major depression
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Functional connectivity between prefrontal cortex and subgenual cingulate predicts antidepressant effects of ketamine
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1016/j.euroneuro.2019.02.008
dcterms.bibliographicCitation.journaltitle
European Neuropsychopharmacology
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Elsevier
dcterms.bibliographicCitation.pagestart
501
dcterms.bibliographicCitation.pageend
508
dcterms.bibliographicCitation.volume
29
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Original article first published: 2019-02-26.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30819549
dcterms.isPartOf.eissn
1873-7862