dc.contributor.author
Buttgereit, Thomas
dc.contributor.author
Palmowski, Andriko
dc.contributor.author
Forsat, Noah
dc.contributor.author
Boers, Maarten
dc.contributor.author
Witham, Miles D.
dc.contributor.author
Rodondi, Nicolas
dc.contributor.author
Moutzouri, Elisavet
dc.contributor.author
Navidad, Antonio Jesus Quesada
dc.contributor.author
Van't Hof, Arnoud W. J.
dc.contributor.author
Worp, Bart van der
dc.contributor.author
Coll-Planas, Laura
dc.contributor.author
Voshaar, Marieke
dc.contributor.author
Wit, Maarten de
dc.contributor.author
Silva, José da
dc.contributor.author
Stegemann, Sven
dc.contributor.author
Bijlsma, Johannes W.
dc.contributor.author
Koeller, Marcus
dc.contributor.author
Mooijaart, Simon
dc.contributor.author
Kearney, Patricia M.
dc.contributor.author
Buttgereit, Frank
dc.date.accessioned
2022-01-27T08:27:10Z
dc.date.available
2022-01-27T08:27:10Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31500
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31232
dc.description.abstract
BACKGROUND: older people remain underrepresented in clinical trials, and evidence generated in younger populations cannot always be generalized to older patients.
OBJECTIVE: to identify key barriers and to discuss solutions to specific issues affecting recruitment and retention of older participants in clinical trials based on experience gained from six current European randomised controlled trials (RCTs) focusing on older people.
METHODS: a multidisciplinary group of experts including representatives of the six RCTs held two networking conferences and compiled lists of potential barriers and solutions. Every item was subsequently allocated points by each study team according to how important it was perceived to be for their RCTs.
RESULTS: the six RCTs enrolled 7,612 older patients. Key barriers to recruitment were impaired health status, comorbidities and diverse health beliefs including priorities within different cultural systems. All trials had to increase the number of recruitment sites. Other measures felt to be effective included the provision of extra time, communication training for the study staff and a re-design of patient information. Key barriers for retention included the presence of severe comorbidities and the occurrence of adverse events. Long study duration, frequent study visits and difficulties accessing the study site were also mentioned. Solutions felt to be effective included spending more time maintaining close contact with the participants, appropriate measures to show appreciation and reimbursement of travel arrangements.
CONCLUSION: recruitment and retention of older patients in trials requires special recognition and a targeted approach. Our results provide scientifically-based practical recommendations for optimizing future studies in this population.
en
dc.rights.uri
http://www.fu-berlin.de/sites/refubium/rechtliches/Nutzungsbedingungen
dc.subject
clinical trials
en
dc.subject
older patients
en
dc.subject
older people
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Barriers and potential solutions in the recruitment and retention of older patients in clinical trials-lessons learned from six large multicentre randomized controlled trials
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1093/ageing/afab147
dcterms.bibliographicCitation.journaltitle
Age and Ageing
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.originalpublishername
Oxford University Press (OUP)
dcterms.bibliographicCitation.pagestart
1988
dcterms.bibliographicCitation.pageend
1996
dcterms.bibliographicCitation.volume
50
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Original article first published: 2021-07-29.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
34324628
dcterms.isPartOf.issn
0002-0729
dcterms.isPartOf.eissn
1468-2834