Title:
Animal Models: Value and Translational Potency
Author(s):
Mergenthaler, Philipp; Meisel, Andreas
Year of publication:
2021
Available Date:
2021-08-03T08:23:07Z
Abstract:
Modern biomedical research with the aim of translating research findings into novel therapies to benefit patients relies to a large extent on animal models of human pathophysiology. However, success stories of translational research – i.e. preclinical research that successfully predicts positive outcome of a clinical trial – are scarce. Here, we therefore address the current state of preclinical disease modeling as well as actions that have been taken to improve the translational value of animal models.
Part of Identifier:
ISBN (print): 978-0-12-820493-1
Keywords:
animal models
pathophysiology
disease mechanisms
preclinical randomized controlled trials
modeling of care
DDC-Classification:
570 Biowissenschaften; Biologie
618 Experimentelle Medizin
610 Medizin und Gesundheit
Publication Type:
Buchkapitel
DOI of the Original Publication:
Book Title:
Principles of Translational Science in Medicine - From Bench to Bedside
Copyright Publisher:
Copyright © 2021 Elsevier B.V. All rights reserved.
Correspondence from publisher: "The terms of the contributor agreement allows authors to post their final (not formatted) Word draft of the chapter to their institution’s repository."
Department/institution:
Charité - Universitätsmedizin Berlin
Comments:
Original book chapter first published: 2021-07-23.
