dc.contributor.author
Grabarics, Marko
dc.contributor.author
Lettow, Maike
dc.contributor.author
Kirk, Ansgar T.
dc.contributor.author
von Helden, Gert
dc.contributor.author
Causon, Tim J.
dc.contributor.author
Pagel, Kevin
dc.date.accessioned
2021-07-28T06:21:56Z
dc.date.available
2021-07-28T06:21:56Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31350
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-31084
dc.description.abstract
In a previous work, we explored zone broadening and the achievable plate numbers in linear drift tube ion mobility-mass spectrometry through developing a plate-height model [1]. On the basis of these findings, the present theoretical study extends the model by exploring peak-to-peak resolution and peak capacity in ion mobility separations. The first part provides a critical overview of chromatography-influenced resolution equations, including refinement of existing formulae. Furthermore, we present exact resolution equations for drift tube ion mobility spectrometry based on first principles. Upon implementing simple modifications, these exact formulae could be readily extended to traveling wave ion mobility separations and to cases when ion mobility spectrometry is coupled to mass spectrometry. The second part focuses on peak capacity. The well-known assumptions of constant plate number and constant peak width form the basis of existing approximate solutions. To overcome their limitations, an exact peak capacity equation is derived for drift tube ion mobility spectrometry. This exact solution is rooted in a suitable physical model of peak broadening, accounting for the finite injection pulse and subsequent diffusional spreading. By borrowing concepts from the theoretical toolbox of chromatography, we believe that the present study will help in integrating ion mobility spectrometry into the unified language of separation science.
en
dc.format.extent
16 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
ion mobility spectrometry
en
dc.subject
peak capacity
en
dc.subject
peak resolution
en
dc.subject
traveling wave
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Plate-height model of ion mobility-mass spectrometry: Part 2—Peak-to-peak resolution and peak capacity
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/jssc.202100201
dcterms.bibliographicCitation.journaltitle
Journal of Separation Science
dcterms.bibliographicCitation.number
14
dcterms.bibliographicCitation.pagestart
2798
dcterms.bibliographicCitation.pageend
2813
dcterms.bibliographicCitation.volume
44
dcterms.bibliographicCitation.url
https://doi.org/10.1002/jssc.202100201
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.funding
DEAL Wiley
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1615-9314