dc.contributor.author
Brauns, Katharina
dc.contributor.author
Friedl-Werner, Anika
dc.contributor.author
Maggioni, Martina A.
dc.contributor.author
Gunga, Hanns-Christian
dc.contributor.author
Stahn, Alexander C.
dc.date.accessioned
2021-06-22T10:31:52Z
dc.date.available
2021-06-22T10:31:52Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31115
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30851
dc.description.abstract
Adverse cognitive and behavioral conditions and psychiatric disorders are considered a critical and unmitigated risk during future long-duration space missions (LDSM). Monitoring and mitigating crew health and performance risks during these missions will require tools and technologies that allow to reliably assess cognitive performance and mental well-being. Electroencephalography (EEG) has the potential to meet the technical requirements for the non-invasive and objective monitoring of neurobehavioral conditions during LDSM. Weightlessness is associated with fluid and brain shifts, and these effects could potentially challenge the interpretation of resting state EEG recordings. Head-down tilt bed rest (HDBR) provides a unique spaceflight analog to study these effects on Earth. Here, we present data from two long-duration HDBR experiments, which were used to systematically investigate the time course of resting state electrocortical activity during prolonged HDBR. EEG spectral power significantly reduced within the delta, theta, alpha, and beta frequency bands. Likewise, EEG source localization revealed significantly lower activity in a broad range of centroparietal and occipital areas within the alpha and beta frequency domains. These changes were observed shortly after the onset of HDBR, did not change throughout HDBR, and returned to baseline after the cessation of bed rest. EEG resting state functional connectivity was not affected by HDBR. The results provide evidence for a postural effect on resting state brain activity that persists throughout long-duration HDBR, indicating that immobilization and inactivity per se do not affect resting state electrocortical activity during HDBR. Our findings raise an important issue on the validity of EEG to identify the time course of changes in brain function during prolonged HBDR, and highlight the importance to maintain a consistent body posture during all testing sessions, including data collections at baseline and recovery.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Head-Down Tilt Position, but Not the Duration of Bed Rest Affects Resting State Electrocortical Activity
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
638669
dcterms.bibliographicCitation.doi
10.3389/fphys.2021.638669
dcterms.bibliographicCitation.journaltitle
Frontiers in Physiology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33716785
dcterms.isPartOf.eissn
1664-042X