dc.contributor.author
Seeberger, Peter H.
dc.date.accessioned
2021-06-21T09:23:38Z
dc.date.available
2021-06-21T09:23:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/31088
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30824
dc.description.abstract
The glycocalyx, a thick layer of carbohydrates, surrounds the cell wall of most bacterial and parasitic pathogens. Recognition of these unique glycans by the human immune system results in destruction of the invaders. To elicit a protective immune response, polysaccharides either isolated from the bacterial cell surface or conjugated with a carrier protein, for T-cell help, are administered. Conjugate vaccines based on isolated carbohydrates currently protect millions of people against Streptococcus pneumoniae, Haemophilus influenzae type b, and Neisseria meningitides infections. Active pharmaceutical ingredients (APIs) are increasingly discovered by medicinal chemistry and synthetic in origin, rather than isolated from natural sources. Converting vaccines from biologicals to pharmaceuticals requires a fundamental understanding of how the human immune system recognizes carbohydrates and could now be realized. To illustrate the chemistry-based approach to vaccine discovery, I summarize efforts focusing on synthetic glycan-based medicinal chemistry to understand the mammalian antiglycan immune response and define glycan epitopes for novel synthetic glycoconjugate vaccines against Streptococcus pneumoniae, Clostridium difficile, Klebsiella pneumoniae, and other bacteria. The chemical tools described here help us gain fundamental insights into how the human system recognizes carbohydrates and drive the discovery of carbohydrate vaccines.
en
dc.format.extent
29 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Carbohydrates
en
dc.subject
Chemical biology
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1021/acs.chemrev.0c01210
dcterms.bibliographicCitation.journaltitle
Chemical Reviews
dcterms.bibliographicCitation.number
7
dcterms.bibliographicCitation.pagestart
3598
dcterms.bibliographicCitation.pageend
3626
dcterms.bibliographicCitation.volume
121
dcterms.bibliographicCitation.url
https://doi.org/10.1021/acs.chemrev.0c01210
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
![Dieser Normdateneintrag wurde von einer Benutzerin oder einem Benutzer als gültig bestätigt.](/cache_202e45ad85b55efaeb29160f63cd3f3b/themes/FuCD/images/authority_control/invisible.gif)
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1520-6890
refubium.resourceType.provider
WoS-Alert