dc.contributor.author
Sheriff, Ahmed
dc.contributor.author
Kayser, Stefan
dc.contributor.author
Brunner, Patrizia
dc.contributor.author
Vogt, Birgit
dc.date.accessioned
2021-06-01T05:40:22Z
dc.date.available
2021-06-01T05:40:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/30925
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30664
dc.description.abstract
C-reactive protein (CRP) is the best-known acute phase protein. In humans, almost every type of inflammation is accompanied by an increase of CRP concentration. Until recently, the only known physiological function of CRP was the marking of cells to initiate their phagocytosis. This triggers the classical complement pathway up to C4, which helps to eliminate pathogens and dead cells. However, vital cells with reduced energy supply are also marked, which is useful in the case of a classical external wound because an important substrate for pathogens is disposed of, but is counterproductive at internal wounds (e.g., heart attack or stroke). This mechanism negatively affects clinical outcomes since it is established that CRP levels correlate with the prognosis of these indications. Here, we summarize what we can learn from a clinical study in which CRP was adsorbed from the bloodstream by CRP-apheresis. Recently, it was shown that CRP can have a direct effect on blood pressure in rabbits. This is interesting in regard to patients with high inflammation, as they often become tachycardic and need catecholamines. These two physiological effects of CRP apparently also occur in COVID-19. Parts of the lung become ischemic due to intra-alveolar edema and hemorrhage and in parallel CRP increases dramatically, hence it is assumed that CRP is also involved in this ischemic condition. It is meanwhile considered that most of the damage in COVID-19 is caused by the immune system. The high amounts of CRP could have an additional influence on blood pressure in severe COVID-19.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
CRP–C-reactive protein
en
dc.subject
ischemia/reperfusion injury
en
dc.subject
cardiovascular
en
dc.subject
inflammation
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
C-Reactive Protein Triggers Cell Death in Ischemic Cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
630430
dcterms.bibliographicCitation.doi
10.3389/fimmu.2021.630430
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
12
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
33679775
dcterms.isPartOf.eissn
1664-3224