dc.contributor.author
Netz, Roland R.
dc.contributor.author
Eaton, William A.
dc.date.accessioned
2021-04-09T13:39:55Z
dc.date.available
2021-04-09T13:39:55Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/30291
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-30032
dc.description.abstract
There has been much success recently in theoretically simulating parts of complex biological systems on the molecular level, with the goal of first-principles modeling of whole cells. However, there is the question of whether such simulations can be performed because of the enormous complexity of cells. We establish approximate equations to estimate computation times required to simulate highly simplified models of cells by either molecular dynamics calculations or by solving molecular kinetic equations. Our equations place limits on the complexity of cells that can be theoretically understood with these two methods and provide a first step in developing what can be considered biological uncertainty relations for molecular models of cells. While a molecular kinetics description of the genetically simplest bacterial cell may indeed soon be possible, neither theoretical description for a multicellular system, such as the human brain, will be possible for many decades and may never be possible even with quantum computing.
en
dc.format.extent
3 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
biological uncertainty principle
en
dc.subject
biological complexity
en
dc.subject
computational limits
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::570 Biowissenschaften; Biologie::570 Biowissenschaften; Biologie
dc.title
Estimating computational limits on theoretical descriptions of biological cells
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e2022753118
dcterms.bibliographicCitation.doi
10.1073/pnas.2022753118
dcterms.bibliographicCitation.journaltitle
Proceedings of the National Academy of Sciences
dcterms.bibliographicCitation.number
6
dcterms.bibliographicCitation.volume
118
dcterms.bibliographicCitation.url
https://doi.org/10.1073/pnas.2022753118
refubium.affiliation
Physik
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
0027-8424
dcterms.isPartOf.eissn
1091-6490
refubium.resourceType.provider
WoS-Alert