Both alien plant invasions and soil microplastic pollution have become a concerning threat for terrestrial ecosystems, with consequences on the human well-being. However, our current knowledge of microplastic effects on the successful invasion of plants remains limited, despite numerous studies demonstrating the direct and indirect impacts of microplastics on plant performance. To address this knowledge gap, we conducted a greenhouse experiment involving the mixtures of soil and low-density polyethylene (LDPE) microplastic pellets and fragments at the concentrations of 0, 0.5 % and 2.0 %. Additionally, we included Solidago decurrens (native plant) and S. canadensis (alien invasive plant) as the target plants. Each pot contained an individual of either species, after six-month cultivation, plant biomass and antioxidant enzymes, as well as soil properties including soil moisture, pH, available nutrient, and microbial biomass were measured. Our results indicated that microplastic effects on soil properties and plant growth indices depended on the Solidago species, microplastic shapes and concentrations. For example, microplastics exerted positive effects on soil moisture of the soil with native species but negative effects with invasive species, which were impacted by microplastic shapes and concentrations, respectively. Microplastics significantly impacted catalase (P < 0.05) and superoxide dismutase (P < 0.01), aboveground biomass (P < 0.01), and belowground/aboveground biomass (P < 0.01) of the native species depending on microplastic shapes, but no significant effects on those of the invasive species. Furthermore, microplastics effects on soil properties, nutrient, nutrient ratio, and plant antioxidant enzyme activities contributed to plant biomass differently among these two species. These results suggested that the microplastics exerted a more pronounced impact on native Solidago plants than the invasive ones. This implies that the alien invasive species displays greater resistance to microplastic pollution, potentially promoting their invasion. Overall, our study contributes to a better understanding of the promoting effects of microplastic pollution on plant invasion.
Weniger anzeigenBridge illumination gave rise to night-time illuminated paths across aquatic systems. However, if bridge artificial light at night (ALAN) reach waterbodies, it can result in polarised light pollution (PLP), which might alter the optical conditions of a river by night and potentially interfere with moonlight polarisation signals reflected off the water’s surface. It is a night-time phenomenon that can detrimentally change the behaviour of organisms sensitive to horizontally reflected polarised moonlight, a navigational cue and signal known to be used by flying water-seeking insects to detect suitable aquatic habitats to reproduce and lay eggs. In this study, we quantify the reflection of ALAN-induced polarisation patterns at the water’s surface near seven illuminated bridges crossing the river Spree in Berlin. The photometric data shows that bridge illumination induces PLP, which reflects from the water’s surface when measured at specific locations in space considered as potential flying paths for polarotactic aquatic insects. ALAN-induced polarisation findings at illuminated bridges suggest that PLP is a pollutant that illuminates aquatic areas. It requires better research as it can potentially affect polarimetric navigation in flying aquatic insects. As the extent of light pollution reaches riverine systems and aquatic habitats, the potential effects of PLP on freshwaters need the proper development of sustainable lighting solutions that can aid in preserving riverine nightscapes.
Weniger anzeigenStem cell transplant recipients (SCTR) are imperiled to increased risks after SARS-CoV2 infection, supporting the need for effective vaccination strategies for this vulnerable group. With respect to pediatric patients, data on immunogenicity of SARS-CoV2 mRNA-based vaccination is limited. We therefore comprehensively examined specific humoral, B- and T cell responses in a cohort of 2-19 year old SCTR after the second and third vaccine dose. Only after booster vaccination, transplant recipients reached similar levels of vaccine-specific IgG, IgA and neutralizing antibodies against omicron variant as age-matched controls. Although frequencies of SARS-CoV2 specific B cells increased after the third dose, they were still fourfold reduced in patients compared to controls. Overall, the majority of individuals enrolled mounted SARS-CoV2 Spike protein-specific CD4+ T helper cell responses with patients showing significantly higher portions than controls after the third dose. With respect to functionality, however, SCTR were characterized by reduced frequencies of specific interferon gamma producing CD4+ T cells, along with an increase in IL-2 producers. In summary, our data identify distinct quantitative and qualitative impairments within the SARS-CoV2 vaccination specific B- and CD4+ T cell compartments. More importantly, humoral analyses highlight the need for a booster vaccination of SCTR particularly for development of neutralizing antibodies.
Weniger anzeigen“Vulnerable populations” are experiencing a (re)emphasis in climate change adaptation research and practice even though the concept has long been contested. Adaptation planning is increasingly expected to restore past inequalities and address systemic injustices. Yet, we know little about the role local environmental agencies, bureaucrats, and policy practitioners (can) play in addressing “vulnerable populations”. Drawing from qualitative empirical research in Atlanta, Georgia, the United States, and Jinhua, Zhejiang in China, the local problem recognition about “vulnerable populations” and adaptation decision-making was examined. The findings reveal severe limitations in the way “vulnerable populations” are approached, with certain groups being politically contested and being considered difficult to be prioritized. In both cases, accidental forms of adaptation stand out, which mainly focus on blue-green infrastructure interventions and neighborhood revitalization programs, some of which recreated “vulnerable populations”. The findings hint to vulnerability being more deeply rooted in external conditions to the individual, which requires different policy interventions. The article presents a novel understanding by conceptualizing “vulnerable populations” as an instance of vulnerable political institutions. There’s a need to explore the nature of our political systems, how much inequality we allow and which redistribution mechanisms the state has for addressing interdependent dimensions of inequality. To make “vulnerable populations” finally a front and center concern begs us to radically engage the outside of the conventional adaptation box. Inequality studies offers synergies with adaptation justice discourses and different policy instruments that address the root causes of vulnerability.
Weniger anzeigenNCS1 (Neuronal calcium sensor protein 1) encodes a highly conserved calcium binding protein abundantly expressed in neurons. It modulates intracellular calcium homeostasis, calcium-dependent signaling pathways as well as neuronal transmission and plasticity. Here, we generated a NCS1 knockout human induced pluripotent stem cell (hiPSC) line using CRISPR-Cas9 genome editing. It shows regular expression of pluripotent markers, normal iPSC morphology and karyotype as well as no detectable off-target effects on top 6 potentially affected genes. This newly generated cell line constitutes a valuable tool for studying the role of NCS1 in the pathophysiology of various neuropsychiatric disorders and non-neurological disease.
Weniger anzeigenOceanic igneous rocks throughout the Altai-Sayan Fold Belt (ASFB) in central-southern Siberia are often considered to be late Precambrian–early Paleozoic accreted elements of oceanic crust – often of uncertain paleogeographic or geodynamic origin. We explore the role of suprasubduction zone settings in the formation of different ASFB terranes. Our study offers a non-accretionary perspective on the tectonomagmatic development of basalt-bearing units in the ASFB on the example of the forearc terrane of the Ediacaran–early Cambrian Tannuola-Khamsara island arc (herein termed Sayan-Tuvan forearc zone). We describe the geochemistry, structural geology, and stratigraphic relations of basalts of the Aldynbulak, Uttug-Khaia, and Chingin formations, which are integral parts of the Sayan-Tuvan forearc zone. The Aldynbulak basalt samples mainly fall in the compositional fields of ocean island basalts and enriched mid-ocean ridge basalts (E-MORB) and likely derived from a deep mantle source. The Uttug-Khaia and Chingin basalts are N- and E + T-MORB-like basalts, carrying forearc geochemical signatures. Specifically, the Chingin Formation contains boninite dikes and is associated with a boninite-bearing ophiolite. Boninites are commonly associated with forearc magmatism and thus a forearc formation setting is likely. Tectonic and stratigraphic considerations imply that the Aldynbulak basalts formed first, followed by the Uttug-Khaia and later the Chingin basalts and boninites. A schematic model, involving decompression melting of the mantle, is proposed for the development of the studied forearc basalt suites that are linked with the growth of the Tannuola-Khamsara island arc system 580–540 million years ago.
Weniger anzeigenEfficiently estimating fermionic Hamiltonian expectation values is vital for simulating various physical systems. Classical shadow (CS) algorithms offer a solution by reducing the number of quantum state copies needed, but noise in quantum devices poses challenges. We propose an error-mitigated CS algorithm assuming gate-independent, time-stationary, and Markovian (GTM) noise. For n-qubit systems, our algorithm, which employs the easily prepared initial state vertical bar 0(n)> < 0(n)vertical bar assumed to be noiseless, efficiently estimates k-RDMs with (O) over tilde (kn(k)) state copies and (O) over tilde(root n) calibration measurements for GTM noise with constant fidelities. We show that our algorithm is robust against noise types like depolarizing, damping, and X-rotation noise with constant strengths, showing scalings akin to prior CS algorithms for fermions but with better noise resilience. Numerical simulations confirm our algorithm's efficacy in noisy settings, suggesting its viability for near-term quantum devices.
Weniger anzeigenIn nature, parasite species often coinfect the same host. Yet, it is not clear what drives the natural dynamics of coinfection prevalence. The prevalence of coinfections might be affected by interactions among coinfecting species, or simply derive from parasite diversity. Identifying the relative impact of these parameters is crucial for understanding patterns of coinfections. We studied the occurrence and likelihood of coinfections in natural populations of water fleas (Daphnia magna). Coinfection prevalence was within the bounds expected by chance and parasite diversity had a strong positive effect on the likelihood of coinfections. Additionally, coinfection prevalence increased over the season and became as common as a single infection. Our results demonstrate how patterns of coinfection, and particularly their temporal variation, are affected by overlapping epidemics of different parasites. We suggest that monitoring parasite diversity can help predict where and when coinfection prevalence will be high, potentially leading to increased health risks to their hosts.
Weniger anzeigenAccurate simulation models for water interactions with graphene and graphite are important for nanofluidic applications, but existing force fields produce widely varying contact angles. Our extensive review of the experimental literature reveals extreme variation among reported values of graphene–water contact angles and a clustering of graphite–water contact angles into groups of freshly exfoliated (60° ± 13°) and not-freshly exfoliated graphite surfaces. The carbon–oxygen dispersion energy for a classical force field is optimized with respect to this 60° graphite–water contact angle in the infinite-force-cutoff limit, which in turn yields a contact angle for unsupported graphene of 80°, in agreement with the mean of the experimental results. Interaction force fields for finite cutoffs are also derived. A method for calculating contact angles from pressure tensors of planar equilibrium simulations that is ideally suited to graphite and graphene surfaces is introduced. Our methodology is widely applicable to any liquid-surface combination.
Weniger anzeigenHigher perspective taking skills are associated with better social functioning and improved social relationships. Generally, teachers are willing to take the perspective of their students, but it is unclear whether the same is true for the perspective of parents. As communication and conflicts with parents are pervasive, the motivation and willingness to adopt the perspective of parents in counseling situations should be promoted during university teacher training. Therefore, we investigated the promotion of perspective taking among teachers in training and focused mainly on perspective taking toward parents. We developed a case-based learning task in which teachers in training from Freie Universität Berlin ( N = 515) prepared for a fictitious upcoming consultation with a mother about her son. Because it is unclear if direct instruction for perspective taking is necessary in order to promote it, we also used indirect instruction to investigate whether preparing for the consultation under these instructions fostered the willingness to adopt the perspective of students and parents. In the direct instruction participants were directly told to take the perspective of the fictitious mother when evaluating and developing formulations for the consultation. The indirect instruction did not mention the concept of perspective taking but asked participants to focus on the comprehensibility of the formulations. We obtained three measures: the willingness to take a perspective, the attitude toward another person, and the emotional and empathic language used in written texts. With our main result we demonstrated that the willingness to adopt the perspective of both students and parents could be significantly promoted by both instructions. We further demonstrated that a higher willingness to take another’s perspective is associated with a more positive attitude toward the mother, as well as increased positive emotions and empathic concern. Additionally, we replicated results of a previous study showing a generally higher willingness to take the student perspective prior to the intervention. Results are discussed regarding the benefits of promoting perspective taking, especially toward parents, in teacher education.
Weniger anzeigenThe way we establish meaning has been a profound question not only in language research but in developmental science as well. The relation between linguistic form and content has been loosened up in recent pragmatic approaches to communication, showing that code-based models of language comprehension must be augmented by context-sensitive, pragmatic-inferential mechanisms to recover the speaker’s intended meaning. Language acquisition has traditionally been thought to involve building a mental lexicon and extracting syntactic rules from noisy linguistic input, while communicative-pragmatic inferences have also been argued to be indispensable. Recent research findings exploring the electrophysiological indicator of semantic processing, the N400, have raised serious questions about the traditional separation between semantic decoding and pragmatic inferential processes. The N400 appears to be sensitive to mentalization—the ability to attribute beliefs to social partners—already from its developmental onset. This finding raises the possibility that mentalization may not simply contribute to pragmatic inferences that enrich linguistic decoding processes but that the semantic system may be functioning in a fundamentally mentalistic manner. The present review first summarizes the key contributions of pragmatic models of communication to language comprehension. Then, it provides an overview of how communicative intentions are interpreted in developmental theories of communication, with a special emphasis on mentalization. Next, it discusses the sensitivity of infants to the information-transmitting potential of language, their ability to pick up its code-like features, and their capacity to track language comprehension of social partners using mentalization. In conclusion, I argue that the recovery of meaning during linguistic communication is not adequately modeled as a process of code-based semantic retrieval complemented by pragmatic inferences. Instead, the semantic system may establish meaning, as intended, during language comprehension and acquisition through mentalistic attribution of content to communicative partners.
Weniger anzeigenIntroduction: Ethiopia has a rapidly growing small ruminant sector, which faces low productivity due to husbandry practices and poor health condition of the animals. A study was conducted in Ethiopia’s largest municipal abattoir with the objective to assess the health problems of sheep and goats presented for slaughter using standard ante-mortem and post-mortem methodology.
Methods: A cross-sectional study using systematic random sampling was conducted on 384 sheep and 384 goats from January to July 2014.
Results: Soiled skin (69.1%), poor body condition (24.3%), and nostril discharge (19.5%) were common among both species at ante-mortem examination. Gross lesions were frequent in livers (39.7%) and lungs (37.2%), while pneumonia (18.1%) and adhesions (13.8%) were frequent in the lungs of sheep and goats, indicating stress-related illness. Parasitic lesions, especially fasciolosis (19.3%) and hydatid cysts (8.1%) were significantly more common in sheep livers (p 0.05). The direct financial loss from lesions in both species was 1,077,015 ETB or 53,851 USD per year, most of which was estimated to occur from carcass bruising.
Discussion: The findings indicate that reducing parasite burden and preventing carcass bruising through improved handling could significantly increase the profitability of the small ruminant meat sector in Ethiopia..
Weniger anzeigenWriting and reading of magnetization states via mechanical strain are crucial for the development of ultralow-power spintronic devices. In this study, a van der Waals magnetic tunnel junction (vdW MTJ) of Fe3GaTe2/h-BN/MnBi2Te4 is constructed to explore the magnetization reversal under in-plane biaxial strains. Interestingly, the interlayer magnetic coupling of devices can be tuned to ferromagnetic and antiferromagnetic states by tensile and compressive strains, respectively. The various magnetic couplings on applied strains are analyzed using the superexchange theory. Importantly, the interlayer coupling nearly vanishes after removing external strains, ensuring the nonvolatility of magnetization reversal, resulting in the nonvolatile writing of magnetization states in the present vdW MTJ. Moreover, the tunneling magnetoresistance ratio of the device is up to −5745%, which remains −1478% even with −2% strain, showing great potential for reading the magnetization states. Therefore, this work provides an alternate avenue to write and read magnetization states in one vdW MTJ under biaxial strains.
Weniger anzeigenInspired by the specificity of α-(2,9)-sialyl epitopes in bacterial capsular polysaccharides (CPS), a doubly fluorinated disaccharide has been validated as a vaccine lead against Neisseria meningitidis serogroups C and/or B. Emulating the importance of fluorine in drug discovery, this molecular editing approach serves a multitude of purposes, which range from controlling α-selective chemical sialylation to mitigating competing elimination. Conjugation of the disialoside with two carrier proteins (CRM197 and PorA) enabled a semisynthetic vaccine to be generated; this was then investigated in six groups of six mice. The individual levels of antibodies formed were compared and classified as highly glycan-specific and protective. All glycoconjugates induced a stable and long-term IgG response and binding to the native CPS epitope was achieved. The generated antibodies were protective against MenC and/or MenB; this was validated in vitro by SBA and OPKA assays. By merging the fluorinated glycan epitope of MenC with an outer cell membrane protein of MenB, a bivalent vaccine against both serogroups was created. It is envisaged that validation of this synthetic, fluorinated disialoside bioisostere as a potent antigen will open new therapeutic avenues.
Weniger anzeigenBackground
Internet use disorders (IUD) have been recognized as a serious mental health concern. In order to promote consensus on core features of IUD, further studies involving clinical samples are required.
Aims
A clinical evaluation of patients with IUD was conducted as part of the scientific monitoring of a novel online short-term therapy, embedded in the randomized controlled trial Stepped Care Approach for Problematic Internet use Treatment (SCAPIT; ID: DRKS00025994).
Methods
An online diagnostic and a clinical assessment were performed at the baseline measurement of the online intervention. The self-report version of the Assessment of Internet and Computer Game Addiction (AICA-S) was applied to assess symptom severity of IUD. The impact of psychopathological symptoms and impairments of functioning on IUD symptomatology was examined in the sample of patients. Based on a dichotomous classification of the symptom severity of IUD, differences among participants presenting moderate compared to severe addictive Internet behavior were analyzed.
Results
The sample of this an analysis consisted of 57 patients (57.9% males, mean age of 29.12 years) participating in the online short-term therapy for IUD. Based on the AICA-S sum score (M = 11.60; SD = 3.30) participants exhibited moderate (n = 44; 77.2%) to severe (n = 13; 22.8%) symptoms of addictive Internet use. Psychopathological symptoms and impairments of psychosocial functioning had an effect on symptom severity of IUD. Participants with severe symptoms of IUD showed higher psychopathological strains compared to patients with moderate addictive Internet behavior.
Conclusions
The clinical evaluation of patients participating in a novel online short-term therapy for IUD indicated that psychopathological symptoms and impairments of functioning have an impact on addictive Internet behaviors and consequently, need to be addressed in the treatment of IUD. Based on the results, further implications for clinical practice and research on addictive Internet behavior are derived.
Weniger anzeigenRedox reactions play fundamental roles in life and are at the core of metabolism. Thus, observing and quantifying these reactions is crucial for diagnostics and therapy. Recent advances in inorganic fluorescent nanoprobes have revolutionized the field, enabling in vitro diagnostics by providing reliable tools for real-time, quantitative determination of redox biomolecule levels in biological samples and cells. Due to their high stability, these probes are also widely used in bioimaging, providing real-time information for in vivo diagnostics and guiding treatment of diseases associated with redox biomolecules. This review explores the diverse landscape of inorganic fluorescent nanoprobes designed for the detection of biologically relevant reactive oxygen and nitrogen species. The discussion is divided into several sections, each focusing on nanoprobes tailored for specific oxidative species. The impact of tailored nanoprobes in diagnostics and imaging-guided treatment depends on their chemical composition, surface property, and fluorescence mechanism. The discussions highlight the current strengths and weaknesses, which will help to design more efficient redox-responsive inorganic fluorescent nanoprobes in the future.
Weniger anzeigenBefore the end of its mission, the Cassini spacecraft orbited Saturn in a series of highly inclined elliptical ‘Ring-Grazing’ orbits (RGO). During the RGO, the spacecraft passed repeatedly through the ring plane outside the F ring, near the orbits of Janus and Epimetheus, at an average relative speed of ∼20 km s–1. For the first time, Cassini’s Cosmic Dust Analyser (CDA) directly sampled dust particles from this region. Here, we analyse the compositions of dust grains sampled within ±15 min relative to nine ring plane crossings of the RGO. The compositions of most analysed RGO grains are similar to those of E ring ice grains, implying that the E ring extends to within at least 2.45 Saturn radii (RS) of Saturn. The compositional distribution of these grains point at a similar average period (decades) since ejection from Enceladus as of particles in the outer E ring (beyond 8 RS). Higher fractions of larger grains are found near the orbits of Janus and Epimetheus, which probably represent ejecta from these moons. Most of these grains have compositions similar to the background E ring grains, indicating that E ring material is coating the surfaces of Janus and Epimetheus. We also report the detection of several types of mineral grains on prograde orbits, one of which, a water ice/silicate mixture, has never been observed by CDA elsewhere. These mineral grains appear to have a different origin from the E ring, and may arise from nearby moons, the F ring, or main rings.
Weniger anzeigenWe introduce the concept of energy-variational solutions for hyperbolic conservation laws. Intrinsically, these energy-variational solutions fulfill the weak-strong uniqueness principle and the semi-flow property, and the set of solutions is convex and weakly-star closed. The existence of energy-variational solutions is proven via a suitable time-discretization scheme under certain assumptions. This general result yields existence of energy-variational solutions to the magnetohydrodynamical equations for ideal incompressible fluids and to the Euler equations in both the incompressible and the compressible case. Moreover, we show that energy-variational solutions to the Euler equations coincide with dissipative weak solutions.
Weniger anzeigenLitter decomposition is a key ecosystem process, relevant for the release and storage of nutrients and carbon in soil. Soil fungi are one of the dominant drivers of organic matter decomposition, but fungal taxa differ substantially in their functional ability to decompose plant litter. Knowledge is mostly based on observational data and subsequent molecular analyses and in vitro studies have been limited to forest ecosystems. In order to better understand functional traits of saprotrophic soil fungi in grassland ecosystems, we isolated 31 fungi from a natural grassland and performed several in vitro studies testing for i) leaf and wood litter decomposition, ii) the ability to use carbon sources of differing complexity, iii) the enzyme repertoire. Decomposition strongly varied among phyla and isolates, with Ascomycota decomposing the most and Mucoromycota decomposing the least. The phylogeny of the fungi and their ability to use complex carbon were the most important predictors for decomposition. Our findings show that it is crucial to understand the role of individual members and functional groups within the microbial community. This is an important way forward to understand the role of microbial community composition for the prediction of litter decomposition and subsequent potential carbon storage in grassland soils.
Weniger anzeigenTo create coherent visual experiences, the brain spatially integrates the complex and dynamic information it receives from the environment. We previously demonstrated that feedback-related alpha activity carries stimulus-specific information when two spatially and temporally coherent naturalistic inputs can be integrated into a unified percept. In this study, we sought to determine whether such integration-related alpha dynamics are triggered by categorical coherence in visual inputs. In an EEG experiment, we manipulated the degree of coherence by presenting pairs of videos from the same or different categories through two apertures in the left and right visual hemifields. Critically, video pairs could be video-level coherent (i.e., stem from the same video), coherent in their basic-level category, coherent in their superordinate category, or incoherent (i.e., stem from videos from two entirely different categories). We conducted multivariate classification analyses on rhythmic EEG responses to decode between the video stimuli in each condition. As the key result, we significantly decoded the video-level coherent and basic-level coherent stimuli, but not the superordinate coherent and incoherent stimuli, from cortical alpha rhythms. This suggests that alpha dynamics play a critical role in integrating information across space, and that cortical integration processes are flexible enough to accommodate information from different exemplars of the same basic-level category.
NEW & NOTEWORTHY Our brain integrates dynamic inputs across the visual field to create coherent visual experiences. Such integration processes have previously been linked to cortical alpha dynamics. In this study, the integration-related alpha activity was observed not only when snippets from the same video were presented, but also when different video snippets from the same basic-level category were presented, highlighting the flexibility of neural integration processes.
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