Bicyclic boronates have recently emerged as promising candidates to invoke targeted biomolecular interactions, given their selectivity for specific functionalities. Despite this, the general stability of the C–B bond in vivo, for such heterocycles, remains an intractable challenge that can often preclude their utility in drug discovery. To address this challenge, de novo strategies that allow expedient access to strategically substituted boronates, that enable modulation of the C–B bond are urgently required. Herein we disclose an operationally simple, regioselective cross-coupling/cyclisation reaction of easily accessible vicinal boronic esters with 2-halophenols to rapidly forge 3-substituted bicyclic boronates. The utility of the platform was demonstrated via expedient access to Xeruborbactam derivatives, chemoselective manipulation of formed products and the convergent approach to bicyclic boronates with a pendent biomolecular probe.

Resources are central to value creation processes. Hence, marketing and service research rely heavily on conceptualisations of resources and resource integration for theory building efforts. One of the most widely accepted marketing lenses on resources and resource integration is the service-dominant (S-D) logic. Depicting resources as becoming and contextual, S-D logic argues that their usefulness co-depends on other resources. Some assumptions of S-D logic have been challenged particularly its dichotomous categorisation of operand and operant resources. To inform ongoing S-D logic theorising, our article problematises the multiple and contradictory ontological views upon resources and resource integration present within S-D logic. Moving beyond critique, we propose concrete means for reconciling these contradictions. Seeing a parallel between S-D logic’s ontological inconsistencies and past ontological disagreements in the philosophy of science, we draw on the philosophical perspective of Karen Barad to develop a consistent onto-epistemological foundation for conceptualising the becoming nature of resources in S-D logic. The theory adaptation we perform enhances the applicability and explanatory capacity of S-D logic, while also offering a more robust and rigorous foundation for marketing and service research at large and giving managers new means to make sense of co-dependent resource phenomena.

Precise means of characterizing analog quantum simulators are key to developing quantum simulators capable of beyond-classical computations. Here, we precisely estimate the free Hamiltonian parameters of a superconducting-qubit analog quantum simulator from measured time-series data on up to 14 qubits. To achieve this, we develop a scalable Hamiltonian learning algorithm that is robust against state-preparation and measurement (SPAM) errors and yields tomographic information about those SPAM errors. The key subroutines are a novel super-resolution technique for frequency extraction from matrix time-series, tensorESPRIT, and constrained manifold optimization. Our learning results verify the Hamiltonian dynamics on a Sycamore processor up to sub-MHz accuracy, and allow us to construct a spatial implementation error map for a grid of 27 qubits. Our results constitute an accurate implementation of a dynamical quantum simulation that is precisely characterized using a new diagnostic toolkit for understanding, calibrating, and improving analog quantum processors.

Magnetic adatoms on superconductors give rise to Yu-Shiba-Rusinov (YSR) states that hold considerable interest for the design of topological superconductivity. Here, we show that YSR states are also an ideal platform to engineer structures with intricate wave function symmetries. We assemble structures of iron atoms on the quasi-two-dimensional superconductor 2H-NbSe2. The Yu-Shiba-Rusinov wave functions of individual atoms extend over several nanometers enabling hybridization even at large adatom spacing. We show that the substrate can be exploited to deliberately break symmetries of the adatom structure leading to hybridized YSR states exhibiting symmetries that cannot be found in orbitals of iso-structural planar molecules in the gas phase. We exploit this potential by designing chiral YSR wave functions of triangular adatom structures. Our results significantly expand the range of interesting quantum states that can be engineered using arrays of magnetic adatoms on superconductors.

In their attempt to reposition Germany in an international context after World War II, actors from both the fine arts and the literary scene turned to the idea of art as a universal language. Two major projects that shaped the West German cultural sphere in the 1950 s and 1960s – the contemporary art exhibition documenta 2 and Hans Magnus Enzensberger’s anthology Museum der modernen Poesie – placed this idea at their conceptual core. The debates surrounding these projects show, however, that the notion of art as a universal language was as contested as it was compelling. In close readings of paratexts, including previously overlooked archival material, it becomes evident that very different conceptualizations of monolingualism and community are attached to the idea in each context. Evaluating these differences through the lens of translation studies, curatorial studies, and political theory enables a more nuanced discussion of the concept’s post-war renaissance and its ideological implications.

Background

The 2018 European Society of Cardiology (ESC)/European Society of Hypertension (ESH) guidelines for the management of hypertension highlight the importance of fixed-dose combinations (FDC) for the treatment of hypertension and recommend initial single-pill combination therapy in almost all patients. However, data on the implementation of these recommendations in clinical practice are scarce.

Methods

Data from the German Institute for Drug Use Evaluation (DAPI) were analyzed and extrapolated accounting for approximately 88% of Germany’s population (approximately 73.3 million subjects). All antihypertensive (AHT) FDC products available on the German market were included in the analyses. We examined the time course of dispensed packages between January 2016 and December 2020.

Results

FDCs accounted for 15.4% of all AHT in 2016 and for 10.9% in 2020. While dispensing of all AHT increased slightly from year to year (2016: 143.8 million, 2020: 153.2 million packs), dispensing of FDCs decreased from 22.2 million (2016) to 16.6 million (2020) packs. Dispensing of FDCs containing hydrochlorothiazide (HCT) declined considerably from 2016 to 2020 (Q1 2016: 4.65 million, Q4 2020: 3.13 million packs). Accordingly, the proportion of HCT-containing combinations in all FDCs decreased from 85.3 to 74.2% from Q1 2016 to Q4 2020. Patients younger than 80 years were prescribed FDCs more frequently (14.6% of all AHT, based on the entire evaluation period) than patients 80 years and older (10.0%). In both age groups, this proportion decreased continuously over time.

Conclusions

Almost 2 years following the release of the 2018 ESC/ESH guidelines, only 10.9% of the prescribed packs of antihypertensive drugs in 2020 were FDC products, documenting underutilization of current guideline recommendations on pharmacotherapy in hypertension. Structured programs to evidence-based decision support are required to improve guideline inertia and patient outcomes, eventually.

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary health. Despite global efforts to mitigate legacy pollutants, the continuous introduction of new substances remains a major threat to both people and the planet. In response, global initiatives are focusing on risk assessment and regulation of emerging contaminants, as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals, Waste, and Pollution Prevention. This review identifies the sources and impacts of emerging contaminants on planetary health, emphasizing the importance of adopting a One Health approach. Strategies for monitoring and addressing these pollutants are discussed, underscoring the need for robust and socially equitable environmental policies at both regional and international levels. Urgent actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

Context. Since the discovery of the first exoplanet almost three decades ago, the number of known exoplanets has increased dramatically. By beginning of the 2000s it was clear that dedicated facilities to advance our studies in this field were needed. The CHaracterising ExOPlanet Satellite (CHEOPS) is a space telescope specifically designed to monitor transiting exoplanets orbiting bright stars. In September 2023, CHEOPS completed its nominal mission duration of 3.5 yr and remains in excellent operational conditions. As a testament to this, the mission has been extended until the end of 2026.

Aims. Scientific and instrumental data have been collected throughout in-orbit commissioning and nominal operations, enabling a comprehensive analysis of the mission’s performance. In this article, we present the results of this analysis with a twofold goal. First, we aim to inform the scientific community about the present status of the mission and what can be expected as the instrument ages. Secondly, we intend for this publication to serve as a legacy document for future missions, providing insights and lessons learned from the successful operation of CHEOPS.

Methods. To evaluate the instrument performance in flight, we developed a comprehensive monitoring and characterisation (M&C) programme. It consists of dedicated observations that allow us to characterise the instrument’s response and continuously monitor its behaviour. In addition to the standard collection of nominal science and housekeeping data, these observations provide valuable input for detecting, modelling, and correcting instrument systematics, discovering and addressing anomalies, and comparing the instrument’s actual performance with expectations.

Results. The precision of the CHEOPS measurements has enabled the mission objectives to be met and exceeded. The satellite’s performance remains stable and reliable, ensuring accurate data collection throughout its operational life. Careful modelling of the instrumental systematics allows the data quality to be significantly improved during the light curve analysis phase, resulting in more precise scientific measurements.

Conclusions. CHEOPS is compliant with the driving scientific requirements of the mission. Although visible, the ageing of the instrument has not affected the mission’s performance. The satellite’s capabilities remain robust, and we are confident that we will continue to acquire high-quality data during the mission extension.

Context. The TOI-178 system consists of a nearby, late-K-dwarf with six transiting planets in the super-Earth to mini-Neptune regime, with radii ranging from to 2.9 R⊕ and orbital periods between 1.9 and 20.7 days. All the planets, but the innermost one, form a chain of Laplace resonances. The fine-tuning and fragility of such orbital configurations ensure that no significant scattering or collision event has taken place since the formation and migration of the planets in the protoplanetary disc, thereby providing important anchors for planet formation models.

Aims. We aim to improve the characterisation of the architecture of this key system and, in particular, the masses and radii of its planets. In addition, since this system is one of the few resonant chains that can be characterised by both photometry and radial velocities, we propose to use it as a test bench for the robustness of the planetary mass determination with each technique.

Methods. We performed a global analysis of all the available photometry from CHEOPS, TESS and NGTS, and radial velocity from ESPRESSO, using a photo-dynamical modelling of the light curve. We also tried different sets of priors on the masses and eccentricity, as well as different stellar activity models, to study their effects on the masses estimated by transit-timing variations (TTVs) and radial velocities (RVs).

Results. We demonstrate how stellar activity prevents a robust mass estimation for the three outer planets using radial velocity data alone. We also show that our joint photo-dynamical and radial velocity analysis has resulted in a robust mass determination for planets c to 𝑔, with precision of ~ 12% for the mass of planet c, and better than 10% for planets d to 𝑔. The new precisions on the radii range from 2 to 3%. The understanding of this synergy between photometric and radial velocity measurements will be valuable for the PLATO mission. We also show that TOI-178 is indeed currently locked in the resonant configuration, librating around an equilibrium of the chain.

The TESS mission searches for transiting exoplanets by monitoring the brightness of hundreds of thousands of stars across the entire sky. M-type planet hosts are ideal targets for this mission due to their smaller size and cooler temperatures, which makes it easier to detect smaller planets near or within their habitable zones. Additionally, M dwarfs have a smaller contrast ratio between the planet and the star, making it easier to measure the planet’s properties accurately. Here, we report the validation analysis of 13 TESS exoplanet candidates orbiting around M dwarfs. We studied the nature of these candidates through a multi-colour transit photometry transit analysis using several ground-based instruments (MuSCAT2, MuSCAT3, and LCO-SINISTRO), high-spatial resolution observations, and TESS light curves. We present the validation of five new planetary systems: TOI-1883b, TOI-2274b, TOI-2768b, TOI-4438b, and TOI-5319b, along with compelling evidence of a planetary nature for TOIs 2781b and 5486b. We also present an empirical definition for the Neptune desert boundaries. The remaining six systems could not be validated due to large true radius values overlapping with the brown dwarf regime or, alternatively, the presence of chromaticity in the MuSCAT2 light curves.

With sizable volatile envelopes but smaller radii than the solar system ice giants, sub-Neptunes have been revealed as one of the most common types of planet in the galaxy. While the spectroscopic characterization of larger sub-Neptunes (2.5–4 R⊕) has revealed hydrogen-dominated atmospheres, smaller sub-Neptunes (1.6–2.5 R⊕) could either host thin, rapidly evaporating, hydrogen-rich atmospheres or be stable, metal-rich "water worlds" with high mean molecular weight atmospheres and a fundamentally different formation and evolutionary history. Here, we present the 0.6–2.8 μm JWST/NIRISS/SOSS transmission spectrum of GJ 9827 d, the smallest (1.98 R⊕) warm (Teq,A=0.3 ∼ 620 K) sub-Neptune where atmospheric absorbers have been detected to date. Our two transit observations with NIRISS/SOSS, combined with the existing HST/WFC3 spectrum, enable us to break the clouds–metallicity degeneracy. We detect water in a highly metal-enriched "steam world" atmosphere (O/H of ∼4 by mass and H2O found to be the background gas with a volume mixing ratio of >31%). We further show that these results are robust to stellar contamination through the transit light source effect. We do not detect escaping metastable He, which, combined with previous nondetections of escaping He and H, supports the steam atmosphere scenario. In water-rich atmospheres, hydrogen loss driven by water photolysis happens predominantly in the ionized form, which eludes observational constraints. We also detect several flares in the NIRISS/SOSS light curves with far-UV energies of the order of 1030 erg, highlighting the active nature of the star. Further atmospheric characterization of GJ 9827 d probing carbon or sulfur species could reveal the origin of its high metal enrichment.

This article describes FloraVeg.EU, a new online database with open-access information on European vegetation units (phytosociological syntaxa), vegetated habitats, and plant taxa. It consists of three modules. (1) The Vegetation module includes 149 phytosociological classes, 378 orders and 1305 alliances of an updated version of the EuroVegChecklist modified based on the decisions of the European Vegetation Classification Committee. Vegetation units dominated by vascular plants are characterized by country-based distribution maps and data on the dominant life forms, phenology, soil properties, relationships to vegetation regions, elevational vegetation belts and azonal habitats, successional status, and degree of naturalness. A list of diagnostic taxa is also provided for each class. (2) The Habitats module includes vascular-plant-dominated terrestrial, freshwater, and marine habitat types from the first to the third or fourth highest hierarchical levels of the EUNIS classification. Of these, 249 vegetated habitats are characterized by a brief description, a point-based distribution map, diagnostic, constant, and dominant taxa, and a list of the corresponding alliances. (3) The Species module provides information on 37 characteristics of European vascular plant species and some infrageneric or infraspecific taxa, including functional traits (habitus and growth type, leaf, flower, fruit and seed traits, and trophic mode), taxon origin (native vs alien), and ecological information (environmental relationships, Ellenberg-type indicator values, disturbance indicator values, and relationships to vegetation units and habitat types). Values for at least three variables are available for 36,404 species. Individual taxa, vegetation units, and habitats in these three modules are illustrated by more than 34,000 photographs. The Download section of FloraVeg.EU provides open-access data sets in a spreadsheet format that can be used for analyses. FloraVeg.EU is a new resource with easily accessible data that can be used for research in vegetation science, ecology, and biogeography, as well as for education and conservation applications.

The hyperarid Atacama Desert is one of the driest and oldest deserts on Earth, rendering it a valuable climate archive. However, unraveling its past climate is particularly challenging and the few studied paleoclimate records of the region reveal strong temporal and spatial variabilities. To enhance our understanding of these dynamics we investigated a sedimentary record in the Yungay valley located in the southern hyperarid Atacama Desert. We employed paleomagnetic and radiocarbon dating, and for the first time for Atacama Desert sediments, a meteoric 10Be/9Be based method for determining the depositional age. The respective 4.20 m deep profile comprises a lower alluvial fan deposit with a maximum age of 3.8 ± 0.8 Ma, and an upper 1.84 m thick clay pan deposit that has accumulated over the last 19 ka. Different proxies including grain size, salt concentration, and elemental composition indicate an aridity increase around 2.3 Ma ago and repeated dry and wet phases during the late Pleistocene and the Holocene. The latter climatic shifts can be assigned to variabilities of the South American Summer Monsoon and El Niño Southern Oscillation with moisture sources from the Atlantic and the Pacific Ocean, respectively. This study provides deeper insights into the heterogeneous climate of the hyperarid Atacama Desert and underlines the importance of interdisciplinary investigations to decipher climate systems and their effect on potential habitable regions in such an extreme environment.

We synthesize research from complementary scientific fields to address the likely future extent and duration of the proposed Anthropocene epoch. Intensification of human-forced climate change began from about 1970 onwards with steepening increases in greenhouse gases, ocean acidification, global temperature and sea level, along with ice loss. The resulting distinction between relatively stable Holocene climatic conditions and those of the proposed Anthropocene epoch is substantial, with many aspects irreversible. The still-rising trajectory of greenhouse gas emissions is leading to yet greater and more permanent divergence of the Anthropocene from the Holocene Earth System. We focus here on the effects of the ensuing climate transformation and its impact on the likely duration of this novel state of the Earth System. Given the magnitude and rapid rise of atmospheric carbon dioxide (CO2), its long lifetime in the atmosphere, and the present disequilibrium in Earth's energy budget (expressed as the Earth's Energy Imbalance, or EEI), both temperatures and sea level must continue to rise – even with carbon emissions lowered to net zero (where anthropogenic CO2 emissions = anthropogenic CO2 removals) – until the energy budget balance is eventually restored. Even if net zero were achieved immediately, elevated global temperatures would persist for at least several tens of millennia, with expected levels of warmth by the end of this century not seen since the early Late Pliocene. Interglacial conditions are likely to persist for at least 50,000 years under already-accumulated CO2 emissions and Earth's low eccentricity orbit. Continued increases in greenhouse gas emissions are likely to extend that persistence to around 500,000 years, suppressing the pronounced expression of Milankovitch cyclicity typical of the later Pleistocene Epoch. This major perturbation alone is sufficient to justify the Anthropocene as terminating the Holocene Epoch. The wider and mostly irreversible effects of climate change, not least in amplifying reconfiguration of the biosphere, emphasize the scale of this departure from Holocene conditions, justifying the establishment of a new epoch. Given such perspectives, the Anthropocene epoch represents what will become a lasting and substantial change in the Earth System. It is the Holocene Epoch at only 11,700 years duration that will appear as the ‘blip’ in the Geological Time Scale, a brief interval when complex, settled human societies co-existed with, but did not overwhelm, a stable Earth System.

Distractor-induced blindness (DIB) describes a reduced access to a cued visual target–if multiple target-like distractors have been presented beforehand. Previous ERP data suggest a cumulative frontal inhibition triggered by distractors, which affects the updating process of the upcoming target. In the present study, we examine whether the modality of the cue—formerly defined in the visual domain–affects the expression of these neural signatures. 27 subjects were tested in a cross-modal DIB task: Distractors and targets were defined by a transient change of stimuli shape in a random-dot kinematogram. The onset of the target was announced by a rise in amplitude of a sinusoidal tone. Behavioral results confirmed that detection of the target relies on the number of preceding distractor episodes. Replicating previous unimodal results, ERP responses to distractors were characterized by a frontal negativity starting at 100 ms, which increases with an increasing number of distractor episodes. However, the processing–and detection–of the target was not characterized by a more-expressed P3 response, but by an occipital negativity. The current data confirm that the neural signatures of target awareness depend on the experimental setup used: In case of the DIB, the cross-modal setting might lead to a reduction of attentional resources in the visual domain.

Was macht eine kunsthistorische Architekturgeschichte aus, welches Erkenntnisinteresse verfolgt sie und was kann sie leisten? Die vorliegende Festschrift zum 65. Geburtstag von Christian Freigang versammelt fünfzehn Beiträge von Weggefährt:innen des Jubilars, die anhand der Beschäftigung mit konkreten Bauten, Bildern und Geschichten vom Mittelalter bis in die Gegenwart zur Beantwortung dieser Fragen beitragen. Die Aufsätze spiegeln eine Auswahl der Themenfelder wider, auf die sich Christian Freigangs Forschungsinteresse richtet und werden von den Herausgeber:innen dialogisch miteinander ins Gespräch gesetzt.

Biological invasions pose a major threat to biodiversity, ecosystem functioning, and human well-being. Non-native species can have severe ecological impacts that are transformative, affecting ecosystems across both short-term and long-term timescales. However, few studies have determined the temporal dynamics of impact between these scales, impeding future predictions as invasion rates continue to rise. Our study uses a meta-analytical approach to dissect the changing taxonomic and functional impacts of biological invasions on native macroinvertebrate populations and communities in freshwater ecosystems across Europe, using a recently collated European long-term time series spanning several decades. Our findings reveal a complex temporal pattern: while initial stages of invasions (i.e. five years after the first record of non-native species) often exhibited benign impacts on macroinvertebrate abundance, richness, or functional diversity, the long-term (i.e. the period following the early invasion) effects became predominantly negative. This pattern was consistent between taxonomic and functional metrics for impacts at both the population and species level, with taxonomic metrics initially positively affected by invasions and functional metrics being more stable before also declining. These results suggest that even initially benign or positively perceived impacts could be eventually superseded by negative consequences. Therefore, understanding the magnitude of invasion effects increasingly requires long-term studies spanning several years or decades to offer insights into effective conservation strategies prioritising immediate and future biodiversity protection efforts. These findings also highlight the importance of integrating multiple taxonomic, functional and temporal components to inform adaptive management approaches to mitigate the negative effects of current and future biological invasions.