dc.contributor.author
Trimpert, Jakob
dc.contributor.author
Vladimirova, Daria
dc.contributor.author
Dietert, Kristina
dc.contributor.author
Abdelgawad, Azza
dc.contributor.author
Kunec, Dusan
dc.contributor.author
Dökel, Simon
dc.contributor.author
Voss, Anne
dc.contributor.author
Gruber, Achim D.
dc.contributor.author
Bertzbach, Luca D.
dc.contributor.author
Osterrieder, Nikolaus
dc.date.accessioned
2021-02-08T14:27:51Z
dc.date.available
2021-02-08T14:27:51Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/29542
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-29286
dc.description.abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated an unprecedented and yet-unresolved health crisis worldwide. Different mammals are susceptible to SARS-CoV-2; however, few species examined so far develop robust clinical disease that mirrors severe human cases or allows testing of vaccines and drugs under conditions of severe disease. Here, we compare the susceptibilities of three dwarf hamster species (Phodopus spp.) to SARS-CoV-2 and introduce the Roborovski dwarf hamster (P. roborovskii) as a highly susceptible COVID-19 model with consistent and fulminant clinical signs. Particularly, only this species shows SARS-CoV-2-induced severe acute diffuse alveolar damage and hyaline microthrombi in the lungs, changes described in patients who succumbed to the infection but not reproduced in any experimentally infected animal. Based on our findings, we propose the Roborovski dwarf hamster as a valuable model to examine the efficacy and safety of vaccine candidates and therapeutics, particularly for use in highly susceptible individuals.
en
dc.format.extent
13 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject
coronavirus disease 2019
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::616 Krankheiten
dc.title
The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
108488
dcterms.bibliographicCitation.doi
10.1016/j.celrep.2020.108488
dcterms.bibliographicCitation.journaltitle
Cell Reports
dcterms.bibliographicCitation.number
10
dcterms.bibliographicCitation.volume
33
dcterms.bibliographicCitation.url
https://doi.org/10.1016/j.celrep.2020.108488
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Virologie
refubium.affiliation.other
Institut für Tierpathologie
refubium.affiliation.other
Tiermedizinisches Zentrum für Resistenzforschung (TZR)
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2211-1247
refubium.resourceType.provider
WoS-Alert