dc.contributor.author
Irmen, Friederike
dc.contributor.author
Karabanov, Anke Ninija
dc.contributor.author
Bögemann, Sophie Alida
dc.contributor.author
Andersen, Kasper Winther
dc.contributor.author
Madsen, Kristoffer Hougaard
dc.contributor.author
Bisgaard, Thue
dc.contributor.author
Dyrby, Tim B.
dc.contributor.author
Siebner, Hartwig Roman
dc.date.accessioned
2021-02-01T13:09:32Z
dc.date.available
2021-02-01T13:09:32Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/29437
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-29183
dc.description.abstract
Introduction: Motor skill learning already triggers the functional reorganization of regional brain activity after short periods of training. Recent studies suggest that microstructural change may emerge at similar timescales, but the spatiotemporal profiles of functional and structural plasticity have rarely been traced in parallel. Recently, we demonstrated that 5 days of endoscopic skill training induces changes in task-related brain activity in the ventral premotor cortex (PMv) and other areas of the frontoparietal grasping network. Here, we analyzed microstructural data, collected during the same experiment to investigate if microstructural plasticity overlaps temporally and spatially with the training-induced changes in task-related brain activity.
Materials and Methods: Thirty-nine students were divided into a full-routine group (n= 20), that underwent three endoscopy training sessions in the MR-scanner as well as a 5-day virtual reality (VR)-endoscopy training and a brief-routine group (n= 19), that only performed the in-scanner endoscopy training sessions. Diffusion Tensor Imaging (DTI)-derived fractional anisotropy (FA) and resting-state functional magnetic resonance imaging (rs-fMRI) were collected at baseline, after the first and after the last VR-training session.
Results: The full-routine group showed significant FA changes in a left-hemispheric subcortical cluster underlying the PMv region, for which we previously demonstrated functional plasticity during endoscopy training in the same sample. Functional (task-related fMRI) and structural (FA) changes showed the largest change from the first to the second scan, suggesting similar temporal dynamics. In the full-routine group, the FA change in the subcortical cluster underlying the left PMv scaled positively with the individual improvement in endoscopic surgery.
Conclusion: Microstructural white-matter plasticity mirrors the spatiotemporal profile of task-dependent plasticity during a 5-day course of endoscopy skill training. The observed similarities motivate future research on the interplay between functional and structural plasticity during early skill acquisition.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
motor learning
en
dc.subject
grasping network
en
dc.subject
sensorimotor
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Functional and Structural Plasticity Co-express in a Left Premotor Region During Early Bimanual Skill Learning
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
310
dcterms.bibliographicCitation.doi
10.3389/fnhum.2020.00310
dcterms.bibliographicCitation.journaltitle
Frontiers in Human Neuroscience
dcterms.bibliographicCitation.originalpublishername
Frontiers Media SA
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32922275
dcterms.isPartOf.eissn
1662-5161