Urban development without adequate soil erosion control measures is becoming a major environmental concern in developing urban areas across Africa. These environmental disturbances encompass rampart Land Use and Land Cover changes (LULC) due to a high population growth rate and increased economic activities. To understand the influence of accelerated LULC changes and urban expansion as major drivers in landscape degradation in the Epworth district of the Harare Metropolitan Province, the RUSLE model was employed. This considers land use, soil, climate and topography as input parameters in the assessment of the extent and impact of these drivers on soil erosion. The Revised Universal Soil Loss Equation (RUSLE) was used to predict the potential erosion between 1984 and 2018 and soil erosion risk for the years 2000 and 2018. The mean rate of the predicted potential soil erosion was 13.2 t ha−1 yr−1 (1984–2018); areas especially vulnerable to erosion were predicted for foot slope areas with direct tributaries to the major streams and steep sloping zones. The average soil erosion risk was estimated at 1.31 t ha−1 yr−1 for the year 2000 and 1.12 t ha−1 yr−1 for 2018. While the overall potential soil loss decreased between 2000 and 2018, the potential soil loss was observed to increase tremendously in residential areas, which doubled in extent between 2000 and 2018. The findings reveal that about 40% of the Epworth district was threatened by unsustainable soil loss resulting from increased soil erosion risk within the built-up areas.