dc.contributor.author
Hiepen, Christian
dc.contributor.author
Mendez, Paul-Lennard
dc.contributor.author
Knaus, Petra
dc.date.accessioned
2020-11-27T15:58:00Z
dc.date.available
2020-11-27T15:58:00Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28971
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28721
dc.description.abstract
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGFβ) superfamily of cytokines. While some ligand members are potent inducers of angiogenesis, others promote vascular homeostasis. However, the precise understanding of the molecular mechanisms underlying these functions is still a growing research field. In bone, the tissue in which BMPs were first discovered, crosstalk of TGFβ/BMP signaling with mechanobiology is well understood. Likewise, the endothelium represents a tissue that is constantly exposed to multiple mechanical triggers, such as wall shear stress, elicited by blood flow or strain, and tension from the surrounding cells and to the extracellular matrix. To integrate mechanical stimuli, the cytoskeleton plays a pivotal role in the transduction of these forces in endothelial cells. Importantly, mechanical forces integrate on several levels of the TGFβ/BMP pathway, such as receptors and SMADs, but also global cell-architecture and nuclear chromatin re-organization. Here, we summarize the current literature on crosstalk mechanisms between biochemical cues elicited by TGFβ/BMP growth factors and mechanical cues, as shear stress or matrix stiffness that collectively orchestrate endothelial function. We focus on the different subcellular compartments in which the forces are sensed and integrated into the TGFβ/BMP growth factor signaling.
en
dc.format.extent
33 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
mechanobiology
en
dc.subject
endothelial-cell
en
dc.subject
shear stress
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
It Takes Two to Tango: Endothelial TGFβ/BMP Signaling Crosstalk with Mechanobiology
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1965
dcterms.bibliographicCitation.doi
10.3390/cells9091965
dcterms.bibliographicCitation.journaltitle
Cells
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
9
dcterms.bibliographicCitation.url
https://doi.org/10.3390/cells9091965
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2073-4409