dc.contributor.author
Stöbener, Daniel David
dc.contributor.author
Weinhart, Marie
dc.date.accessioned
2020-10-29T17:07:24Z
dc.date.available
2020-10-29T17:07:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28722
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28470
dc.description.abstract
Thermoresponsive poly(glycidyl ether) brushes can be grafted to applied tissue culture substrates and used for the fabrication of primary human cell sheets. The self-assembly of such brushes is achieved via the directed physical adsorption and subsequent UV immobilization of block copolymers equipped with a short, photo-reactive benzophenone-based anchor block. Depending on the chemistry and hydrophobicity of the benzophenone anchor, we demonstrate that such block copolymers exhibit distinct thermoresponsive properties and aggregation behaviors in water. Independent on the block copolymer composition, we developed a versatile grafting-to process which allows the fabrication of poly(glycidyl ether) brushes on various tissue culture substrates from dilute aqueous-ethanolic solution. The viability of this process crucially depends on the chemistry and hydrophobicity of, both, benzophenone-based anchor block and substrate material. Utilizing these insights, we were able to manufacture thermoresponsive poly(glycidyl ether) brushes on moderately hydrophobic polystyrene and polycarbonate as well as on rather hydrophilic polyethylene terephthalate and tissue culture-treated polystyrene substrates. We further show that the temperature-dependent switchability of the brush coatings is not only dependent on the cloud point temperature of the block copolymers, but also markedly governed by the hydrophobicity of the surface-bound benzophenone anchor and the subjacent substrate material. Our findings demonstrate that the design of amphiphilic thermoresponsive block copolymers is crucial for their phase transition characteristics in solution and on surfaces.
en
dc.format.extent
22 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
critical aggregation concentration
en
dc.subject
coil-to-globule transition
en
dc.subject
mesoglobules
en
dc.subject
thermal hysteresis
en
dc.subject
physical adsorption
en
dc.subject
C,H-insertion crosslinking
en
dc.subject
grafting density
en
dc.subject
brush conformation
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Thermoresponsive Poly(glycidyl ether) Brush Coatings on Various Tissue Culture Substrates - How Block Copolymer Design and Substrate Material Govern Self-Assembly and Phase Transition
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1899
dcterms.bibliographicCitation.doi
10.3390/polym12091899
dcterms.bibliographicCitation.journaltitle
Polymers
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.originalpublishername
MDPI
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.3390/polym12091899
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie
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refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2073-4360