Title:
Topology-Matching Design of an Influenza-Neutralizing Spiky Nanoparticle-Based Inhibitor with a Dual Mode of Action
Author(s):
Nie, Chuanxiong; Parshad, Badri; Bhatia, Sumati; Cheng, Chong; Stadtmüller, Marlena; Oehrl, Alexander; Kerkhoff, Yannic; Wolff, Thorsten; Haag, Rainer
Year of publication:
2020
Available Date:
2020-10-26T08:22:14Z
Abstract:
In this study, we demonstrate the concept of "topology-matching design" for virus inhibitors. With the current knowledge of influenzaA virus (IAV), we designed a nanoparticle-based inhibitor (nano-inhibitor) that has a matched nanotopology to IAV virions and shows heteromultivalent inhibitory effects on hemagglutinin and neuraminidase. The synthesized nano-inhibitor can neutralize the viral particle extracellularly and block its attachment and entry to the host cells. The virus replication was significantly reduced by 6 orders of magnitude in the presence of the reverse designed nano-inhibitors. Even when used 24hours after the infection, more than 99.999% inhibition is still achieved, which indicates such a nano-inhibitor might be a potent antiviral for the treatment of influenza infection.
Part of Identifier:
ISSN (print): 1433-7851
e-ISSN (online): 1521-3773
Keywords:
antiviral agents
inhibitors
influenza
nanoparticles
topology matching
DDC-Classification:
547 Organische Chemie
Publication Type:
Wissenschaftlicher Artikel
URL of the Original Publication:
DOI of the Original Publication:
Journaltitle:
Angewandte Chemie International Edition
Department/institution:
Biologie, Chemie, Pharmazie
Institut für Chemie und Biochemie / Organische Chemie