dc.contributor.author
Lehner, Lukas J.
dc.contributor.author
Hohberger, Arnim
dc.contributor.author
Marschke, Lisanne
dc.contributor.author
Lachmann, Nils
dc.contributor.author
Peters, Robert
dc.contributor.author
Friedersdorff, Frank
dc.contributor.author
Khadzhynov, Dmytro
dc.contributor.author
Halleck, Fabian
dc.contributor.author
Budde, Klemens
dc.contributor.author
Staeck, Oliver
dc.contributor.author
Duerr, Michael
dc.date.accessioned
2020-10-19T15:54:59Z
dc.date.available
2020-10-19T15:54:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28526
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-28275
dc.description.abstract
The collection of lymphatic fluids (lymphoceles) is a frequent adverse event following renal transplantation. A variety of surgical and medical factors has been linked to this entity, but reliable data on risk factors and long-term outcomes are lacking. This retrospective single-center study included 867 adult transplant recipients who received a kidney transplantation from 2006 to 2015. We evaluated for patient and graft survival, rejection episodes, or detectable donor-specific antibodies (dnDSA) in patients with identified lymphoceles in comparison to controls. We identified 305/867 (35.2%) patients with lymphocele formation, of whom 72/867 (8.3%) needed intervention. Multivariate analysis identified rejection episode as an independent risk factor (OR 1.61, CI 95% 1.17-2.21, p = 0.003) for lymphocele formation, while delayed graft function was independently associated with symptomatic lymphoceles (OR 1.9, CI 95% 1.16-3.12, p = 0.011). Interestingly, there was no difference in detectable dnDSA between groups with a similar graft and patient survival in all groups after 10 years. Lymphoceles frequently occur after transplantation and were found to be independently associated with rejection episodes, while symptomatic lymphoceles were associated with delayed graft function in our cohort. As both are inflammatory processes, they might play a causative role in the formation of lymphoceles. However, development or intervention of lymphoceles did not lead to impaired graft survival in the long-term.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
kidney transplantation
en
dc.subject
adverse events
en
dc.subject
donor specific antibodies
en
dc.subject
allograft rejection
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Analysis of Risk Factors and Long-Term Outcomes in Kidney Transplant Patients with Identified Lymphoceles
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
2841
dcterms.bibliographicCitation.doi
10.3390/jcm9092841
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.number
9
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32887366
dcterms.isPartOf.eissn
2077-0383