Boundaries, limits and frontiers are topics of special interest to those involved in studying interconnectivity among different societies, both past and present. World-Systems Analysis (WSA), derived from World-Systems Theory (WST) is a macro-theoretical perspective which allows approaching interconnectivity in the long-term and in broad territorial scenarios. In this contribution I shall reappraise the key concepts of the original WST, the main theoretical discussions related to WSA, and the incidence of these theoretical approaches in Bronze Age Afro-Eurasian studies.