This chapter presents the idea of integrating central place and central flow theory in order to gain a deeper understanding of economic interactions, ranging from the local to the supra-regional scale. Central place theory is suitable to describe the local exchange relationships between settlements and their hinterland. Central flow theory puts forward the idea of cooperation of specific agents. These agents create new work due to the substitution of imports; an inter-settlement interaction between these agents creates a network of goodand information exchange. Hence, both concepts should be regarded as complementary since they describe two important aspects of the characteristics of places: the relationships to their hinterland and the integration of its people into networks of exchange.