dc.contributor.author
Pieper, Robert
dc.contributor.author
van Best, Niels
dc.contributor.author
van Vorst, Kira
dc.contributor.author
Ebner, Friederike
dc.contributor.author
Reissmann, Monika
dc.contributor.author
Hornef, Mathias W.
dc.contributor.author
Fulde, Marcus
dc.date.accessioned
2020-09-10T13:40:36Z
dc.date.available
2020-09-10T13:40:36Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28240
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27990
dc.description.abstract
Non-communicable diseases, such as the metabolic syndrome and inflammatory bowel disease, constitute serious public health threats in developed countries. Besides environmental factors, genetic predispositions contribute to the onset and progression of the disease.State-of-the-artmouse models recently highlight the involvement of Toll-like receptor 5 (TLR5)-driven microbiota composition in the development of metabolic disorders. Here, we discuss the causes and consequences of an altered enteric microbiota and provide information on a similar mechanism in another species, the pig. We show for the first time that a single nucleotide polymorphism in the porcineTLR5gene conferring impaired functionality is associated with changes in the intestinal microbiota in adult sows and neonatal piglets. Changes in the developing adaptive cellular immune response support the concept of TLR5-driven changes of the microbe-host interplay also in the pig. Together, these findings suggest that pigs with impaired TLR-functionality might represent a model for TLR5-driven diseases in humans.
en
dc.format.extent
8 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Toll-like receptor 5
en
dc.subject
metabolic syndrome
en
dc.subject
inflammatory bowel disease
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::630 Landwirtschaft::630 Landwirtschaft und verwandte Bereiche
dc.title
Toward a porcinein vivomodel to analyze the pathogenesis of TLR5-dependent enteropathies
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1080/19490976.2020.1782163
dcterms.bibliographicCitation.journaltitle
Gut Microbes
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.volume
12
dcterms.bibliographicCitation.url
https://doi.org/10.1080/19490976.2020.1782163
refubium.affiliation
Veterinärmedizin
refubium.affiliation.other
Institut für Mikrobiologie und Tierseuchen
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refubium.funding
Publikationsfonds FU
refubium.note.author
Die Publikation wurde aus Open Access Publikationsgeldern der Freien Universität Berlin gefördert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1949-0976
dcterms.isPartOf.eissn
1949-0984
refubium.resourceType.provider
WoS-Alert