dc.contributor.author
Achazi, Katharina
dc.contributor.author
Haag, Rainer
dc.contributor.author
Ballauff, Matthias
dc.contributor.author
Dernedde, Jens
dc.contributor.author
Kizhakkedathu, Jayachandran N.
dc.contributor.author
Maysinger, Dusica
dc.contributor.author
Multhaup, Gerd
dc.date.accessioned
2021-01-28T06:46:49Z
dc.date.available
2021-01-28T06:46:49Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/28121
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27871
dc.description.abstract
Polyelectrolytes such as e.g. DNA or heparin are long linear or branched macromolecules onto which charges are appended. The counterions neutralizing these charges may dissociate in water and will largely determine the interaction of such polyelectrolytes with biomolecules and in particular with proteins. Here we review studies on the interaction of proteins with polyelectrolytes and how this knowledge can be used for medical applications. Counterion release was identified as the main driving force for the binding of proteins to polyelectrolytes: Patches of positive charge become multivalent counterions of the polyelectrolyte which leads to the release of counterions of the polyelectrolyte and a concomitant increase of entropy. We show this by surveying investigations done on the interaction of proteins with natural and synthetic polyelectrolytes. Special emphasis is laid on sulfated dendritic polyglycerols (dPGS). The entire overview demonstrates that we are moving on to a better understanding of charge‐charge interaction in system of biological relevance. Hence, research along these lines will aid and promote the design of synthetic polyelectrolytes for medical applications.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
polyelectrolyte
en
dc.subject
counterion release
en
dc.subject
sulfated dendritic polyglycerol
en
dc.subject
complement binding
en
dc.subject
inflammation
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.title
Understanding the interaction of polyelectrolyte architectures with proteins and biosystems
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1002/anie.202006457
dcterms.bibliographicCitation.journaltitle
Angewandte Chemie International Edition
dcterms.bibliographicCitation.pagestart
2
dcterms.bibliographicCitation.pageend
25
dcterms.bibliographicCitation.volume
59
dcterms.bibliographicCitation.url
https://doi.org/10.1002/anie.202006457
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.funding
DEAL Wiley
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
1521-3773