dc.contributor.author
Montag, Christiane
dc.contributor.author
Schöner, Johanna
dc.contributor.author
Speck, Lucas Guilherme
dc.contributor.author
Just, Sandra
dc.contributor.author
Stuke, Frauke
dc.contributor.author
Rentzsch, Johannes
dc.contributor.author
Gallinat, Jürgen
dc.contributor.author
Majić, Tomislav
dc.date.accessioned
2020-07-03T11:44:38Z
dc.date.available
2020-07-03T11:44:38Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27455
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27211
dc.description.abstract
Endogenous oxytocin has been associated with different aspects of social cognition in healthy subjects and patients with schizophrenia. In this pilot study, we investigated the relationship between plasma oxytocin and oxytocin level changes induced by empathy-eliciting, attachment-related movie scenes with correlates of cognitive and emotional empathy in patients and healthy controls. The Multifaceted Empathy Test (MET) and the Interpersonal Reactivity Index (IRI) were administered to patients with schizophrenia (N = 35, 12 females) and healthy controls (N = 35, 12 females) to estimate dimensions of cognitive and emotional empathy. Peripheral basal oxytocin concentrations and oxytocin responses to movie-based emotional stimuli were assessed using radioimmunoassay with sample extraction. In patients, induced oxytocin level changes were inversely correlated with MET cognitive empathy regarding negative emotional states. Controlling for non-social cognition and age revealed a significant negative association between basal oxytocin levels and MET cognitive empathy for positive emotions. In healthy subjects, oxytocin reactivity was inversely correlated with the IRI subscale "fantasy". Oxytocin was not related to any measure of emotional empathy. A hyper-reactive oxytocin system might be linked to impaired cognitive empathy as a part of a dysfunctional regulative circuit of attachment-related emotions and interpersonal stressors or threats by attribution of meaning. Healthy adults with a disposition to identify with fictional characters showed lower oxytocin reactivity, possibly indicating familiarity with movie-based stimuli. The oxytocinergic system may be involved in maladaptive coping mechanisms in the framework of impaired mentalizing and associated dysfunctional responses to interpersonal challenges in schizophrenia.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
schizophrenia
en
dc.subject
Multifaceted Empathy Test (MET)
en
dc.subject
Interpersonal Reactivity Index (IRI)
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Peripheral oxytocin is inversely correlated with cognitive, but not emotional empathy in schizophrenia
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e0231257
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0231257
dcterms.bibliographicCitation.journaltitle
PLoS ONE
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Public Library of Science (PLoS)
dcterms.bibliographicCitation.volume
15
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32255800
dcterms.isPartOf.eissn
1932-6203