dc.contributor.author
Kurvits, Lille
dc.contributor.author
Martino, Davide
dc.contributor.author
Ganos, Christos
dc.date.accessioned
2020-07-03T11:35:24Z
dc.date.available
2020-07-03T11:35:24Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/27454
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-27210
dc.description.abstract
The capacity to efficiently control motor output, by either refraining from prepotent actions or disengaging from ongoing motor behaviors, is necessary for our ability to thrive in a stimulus-rich and socially complex environment. Failure to engage in successful inhibitory motor control could lead to aberrant behaviors typified by an excess of motor performance. In tic disorders and Tourette syndrome (TS) - the most common tic disorder encountered in clinics - surplus motor output is rarely the only relevant clinical sign. A range of abnormal behaviors is often encountered which are historically viewed as "disinhibition phenomena". Here, we present the different clinical features of TS from distinct categorical domains (motor, sensory, complex behavioral) that evoke the concept of disinhibition and discuss their associations. We also present evidence for their consideration as phenomena of inhibitory dysfunction and provide an overview of studies on TS pathophysiology which support this view. We then critically dissect the concept of disinhibition in TS and illuminate other salient aspects, which should be considered in a unitary pathophysiological approach. We briefly touch upon the dangers of oversimplification and emphasize the necessity of conceptual diversity in the scientific exploration of TS, from disinhibition and beyond.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Tourette syndrome
en
dc.subject
inhibitory contro
en
dc.subject
disinhibition
en
dc.subject
Gamma aminobutyric acid
en
dc.subject
basal ganglia
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Clinical Features That Evoke the Concept of Disinhibition in Tourette Syndrome
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
21
dcterms.bibliographicCitation.doi
10.3389/fpsyt.2020.00021
dcterms.bibliographicCitation.journaltitle
Frontiers in Phychiatry
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
11
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
32161555
dcterms.isPartOf.eissn
1664-0640