dc.contributor.author
Mieloch, Adam Aron
dc.contributor.author
Richter, Magdalena
dc.contributor.author
Trzeciak, Tomasz
dc.contributor.author
Giersig, Michael
dc.contributor.author
Rybka, Jakub Dalibor
dc.date.accessioned
2020-03-06T10:56:40Z
dc.date.available
2020-03-06T10:56:40Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26953
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26714
dc.description.abstract
The nanoindentation method was applied to determine the elastic modulus and hardness of knee articular cartilage. Cartilage samples from both high weight bearing (HWB) and low weight bearing (LWB) femoral condyles were collected from patients diagnosed with osteoarthritis (OA). The mean elastic modulus of HWB cartilage was 4.46 ± 4.44 MPa in comparison to that of the LWB region (9.81 ± 8.88 MPa, p < 0.001). Similarly, the hardness was significantly lower in HWB tissue (0.317 ± 0.397 MPa) than in LWB cartilage (0.455 ± 0.434 MPa, p < 0.001). When adjusted to patients’ ages, the mean elastic modulus and hardness were both significantly lower in the age group over 70 years (p < 0.001). A statistically significant difference in mechanical parameters was also found in grade 3 and 4 OA. This study provides an insight into the nanomechanical properties of the knee articular cartilage and provides a starting point for personalized cartilage grafts that are compatible with the mechanical properties of the native tissue.
en
dc.format.extent
11 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
articular cartilage
en
dc.subject
osteoarthritis
en
dc.subject
elastic modulus
en
dc.subject
mechanical properties
en
dc.subject
nanoindentation
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::530 Physik::530 Physik
dc.title
Osteoarthritis severely decreases the elasticity and hardness of knee joint cartilage: A nanoindentation study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.3390/jcm8111865
dcterms.bibliographicCitation.journaltitle
Journal of Clinical Medicine
dcterms.bibliographicCitation.url
https://doi.org/10.3390/jcm8111865
refubium.affiliation
Physik
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.eissn
2077-0383