dc.contributor.author
Leiz, Janna
dc.contributor.author
Schmitt-Ott, Kai M.
dc.date.accessioned
2020-01-10T11:49:06Z
dc.date.available
2020-01-10T11:49:06Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26369
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26130
dc.description.abstract
The renal collecting duct fine-tunes urinary composition, and thereby, coordinates key physiological processes, such as volume/blood pressure regulation, electrolyte-free water reabsorption, and acid-base homeostasis. The collecting duct epithelium is comprised of a tight epithelial barrier resulting in a strict separation of intraluminal urine and the interstitium. Tight junctions are key players in enforcing this barrier and in regulating paracellular transport of solutes across the epithelium. The features of tight junctions across different epithelia are strongly determined by their molecular composition. Claudins are particularly important structural components of tight junctions because they confer barrier and transport properties. In the collecting duct, a specific set of claudins (Cldn-3, Cldn-4, Cldn-7, Cldn-8) is expressed, and each of these claudins has been implicated in mediating aspects of the specific properties of its tight junction. The functional disruption of individual claudins or of the overall barrier function results in defects of blood pressure and water homeostasis. In this concise review, we provide an overview of the current knowledge on the role of the collecting duct epithelial barrier and of claudins in collecting duct function and pathophysiology.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
barrier formation
en
dc.subject
collecting duct
en
dc.subject
epithelial barrier
en
dc.subject
tight junction
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Claudins in the Renal Collecting Duct
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
221
dcterms.bibliographicCitation.doi
10.3390/ijms21010221
dcterms.bibliographicCitation.journaltitle
International Journal of Molecular Sciences
dcterms.bibliographicCitation.originalpublishername
MDPI AG
dcterms.bibliographicCitation.volume
21
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31905642
dcterms.isPartOf.eissn
1422-0067