dc.contributor.author
Randriantsilefisoa, Rotsiniaina
dc.contributor.author
Hou, Yong
dc.contributor.author
Pan, Yuanwei
dc.contributor.author
Camacho, José Luis Cuellar
dc.contributor.author
Kulka, Michaël W.
dc.contributor.author
Zhang, Jianguang
dc.contributor.author
Haag, Rainer
dc.date.accessioned
2020-01-06T10:12:46Z
dc.date.available
2020-01-06T10:12:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26322
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-26081
dc.description.abstract
Keeping the stemness of human mesenchymal stem cells (hMSCs) and their adipocyte differentiation potential is critical for clinical use. However, these features are lost on traditional substrates. hMSCs have often been studied on stiff materials whereas culturing hMSCs in their native niche increases their potential. Herein, a patterned hydrogel nanocomposite with the stiffness of liver tissues is obtained without any molding process. To investigate hMSCs' mechanoresponse to the material, the RGD spacing units and the stiffness of the hydrogels are dually tuned via the linker length. This work suggests that hMSCs' locomotion is influenced by the nature of the hydrogel layer (bulk or thin film). Contrary to on bulk surfaces, cell traction occurs during cell spreading on thin films. In addition, hMSCs' spreading behavior varies from shorter to longer linker‐based hydrogels, where on both surfaces hMSCs maintains their stemness as well as their adipogenic differentiation potential with a higher number of adipocytes for nanocomposites with a longer polymer linker. Overall, this work addresses the need for a new alternative for hMSCs culture allowing the cells to differentiate exclusively into adipocytes. This material represents a cell‐responsive platform with a tissue‐mimicking architecture given by the mechanical and morphological properties of the hydrogel.
en
dc.format.extent
14 Seiten
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
dendritic polyglycerol
en
dc.subject
gold nanoparticles
en
dc.subject
human mesenchymal stem cells
en
dc.subject
nanocomposites
en
dc.subject
polyethylene glycol
en
dc.subject.ddc
500 Naturwissenschaften und Mathematik::540 Chemie::547 Organische Chemie
dc.title
Interaction of human mesenchymal stem cells with soft nanocomposite hydrogels based on polyethylene glycol and dendritic polyglycerol
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
1905200
dcterms.bibliographicCitation.doi
10.1002/adfm.201905200
dcterms.bibliographicCitation.journaltitle
Advanced functional materials
dcterms.bibliographicCitation.number
1
dcterms.bibliographicCitation.originalpublishername
Wiley
dcterms.bibliographicCitation.volume
30
dcterms.bibliographicCitation.url
https://doi.org/10.1002/adfm.201905200
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Chemie und Biochemie / Organische Chemie
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refubium.funding
DEAL Wiley
refubium.note.author
Die Publikation wurde von der Freien Universität Berlin finanziert.
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
1616-301X
dcterms.isPartOf.eissn
1616-3028