dc.contributor.author
Iori, Gianluca
dc.contributor.author
Schneider, Johannes
dc.contributor.author
Reisinger, Andreas
dc.contributor.author
Heyer, Frans
dc.contributor.author
Peralta, Laura
dc.contributor.author
Wyers, Caroline
dc.contributor.author
Gräsel, Melanie
dc.contributor.author
Barkmann, Reinhard
dc.contributor.author
Glüer, Claus C.
dc.contributor.author
Bergh, J. P. van den
dc.contributor.author
Pahr, Dieter
dc.contributor.author
Raum, Kay
dc.date.accessioned
2019-12-11T13:51:22Z
dc.date.available
2019-12-11T13:51:22Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26083
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25843
dc.description.abstract
Alterations of structure and density of cortical bone are associated with fragility fractures
and can be assessed in vivo in humans at the tibia. Bone remodeling deficits in aging
women have been recently linked to an increase in size of cortical pores. In this ex vivo
study, we characterized the cortical microarchitecture of 19 tibiae from human donors (aged
69 to 94 years) to address, whether this can reflect impairments of the mechanical competence
of the proximal femur, i.e., a major fracture site in osteoporosis. Scanning acoustic
microscopy (12 μm pixel size) provided reference microstructural measurements at the left
tibia, while the bone vBMD at this site was obtained using microcomputed tomography
(microCT). The areal bone mineral density of both left and right femoral necks (aBMDneck)
was measured by dual-energy X-ray absorptiometry (DXA), while homogenized nonlinear
finite element models based on high-resolution peripheral quantitative computed tomography
provided hip stiffness and strength for one-legged standing and sideways falling loads.
Hip strength was associated with aBMDneck (r = 0.74 to 0.78), with tibial cortical thickness
(r = 0.81) and with measurements of the tibial cross-sectional geometry (r = 0.48 to 0.73) of
the same leg. Tibial vBMD was associated with hip strength only for standing loads (r = 0.59
to 0.65). Cortical porosity (Ct.Po) of the tibia was not associated with any of the femoral
parameters. However, the proportion of Ct.Po attributable to large pores (diameter >
100 μm) was associated with hip strength in both standing (r = -0.61) and falling (r = 0.48)
conditions. When added to aBMDneck, the prevalence of large pores could explain up to
17% of the femur ultimate force. In conclusion, microstructural characteristics of the tibia
reflect hip strength as well as femoral DXA, but it remains to be tested whether such properties
can be measured in vivo.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
cortical bone
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Large cortical bone pores in the tibia are associated with proximal femur strength
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
e0215405
dcterms.bibliographicCitation.doi
10.1371/journal.pone.0215405
dcterms.bibliographicCitation.journaltitle
PLoS ONE
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Public Library of Science (PLoS)
dcterms.bibliographicCitation.volume
14
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.isSupplementedBy.doi
10.5281/zenodo.2605350
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dc.relation.hascorrection
http://doi.org/10.17169/refubium-27867
dcterms.bibliographicCitation.pmid
30995279
dcterms.isPartOf.eissn
1932-6203