dc.contributor.author
Olechowski, Florence
dc.contributor.author
Müller, Rainer H.
dc.contributor.author
Pyo, Sung Min
dc.date.accessioned
2019-12-05T07:43:44Z
dc.date.available
2019-12-05T07:43:44Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/26044
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25803
dc.description.abstract
SmartLipids are the latest generation of dermal lipid nanoparticles with solid particle matrix. Their characteristic properties resulting from the “chaotic” and disordered particle matrix structure are reviewed. These properties are high loading and firm inclusion of active agents, physical stability of the particle matrix lipid modification (primarily α, β′), and related to these three properties the improved chemical stabilization of labile active agents. Exemplarily data for these effects are shown and underlying mechanisms are discussed. Further, general properties of lipid nanoparticles, which are also exhibited by the SmartLipids, are reviewed. These include the restauration of the protective lipid skin barrier (anti-pollution effect), penetration enhancement by occlusion (invisible patch effect) and the option to control the release of active agents for optimized biological effect and reduction of side effects (e.g., skin irritation through sensitizing active agents), which improves the skin tolerability. Regulatory aspects, such as submicron particle status, excipients, and certifications, are also discussed.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
chemical stabilization of active agents
en
dc.subject
controlled release
en
dc.subject
firm inclusion
en
dc.subject
nanostructured lipid carriers (NLCs)
en
dc.subject
penetration enhancement
en
dc.subject
skin occlusion
en
dc.subject
solid lipid nanoparticles
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::615 Pharmakologie, Therapeutik
dc.title
BergaCare SmartLipids
dc.type
Wissenschaftlicher Artikel
dc.title.subtitle
commercial lipophilic active concentrates for improved performance of dermal products
dcterms.bibliographicCitation.doi
10.3762/bjnano.10.208
dcterms.bibliographicCitation.journaltitle
Beilstein J. Nanotechnol.
dcterms.bibliographicCitation.pagestart
2152
dcterms.bibliographicCitation.pageend
2162
dcterms.bibliographicCitation.volume
10
dcterms.bibliographicCitation.url
https://www.beilstein-journals.org/bjnano/articles/10/208
refubium.affiliation
Biologie, Chemie, Pharmazie
refubium.affiliation.other
Institut für Pharmazie
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refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.isPartOf.issn
2190-4286
dcterms.isPartOf.eissn
2190-4286