dc.contributor.author
Jiménez-Fonseca, Paula
dc.contributor.author
Krug, Sebastian
dc.contributor.author
Tamagno, Gianluca
dc.contributor.author
Fierro Maya, Felipe
dc.contributor.author
Monléon Getino, Antonio
dc.contributor.author
Rodriguez Casado, Clara Isabel
dc.contributor.author
Costa, Frederico
dc.contributor.author
Herder, Wouter W. de
dc.contributor.author
Jann, Henning
dc.date.accessioned
2019-09-25T11:24:46Z
dc.date.available
2019-09-25T11:24:46Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/25641
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-25405
dc.description.abstract
Pancreatic neuroendocrine tumours (pNETs) represent rare neoplasms of all NETs often presenting without functional activity. Many sporadic non-functioning pNET patients are already metastatic at the time of diagnosis, and the therapeutic approach to such patients is mostly palliative. In this international, multicentre, retrospective cohort study, we assessed the prognostic value of a set of anthropometric, clinical, biochemical, radiological and pathological parameters at baseline and the impact of the therapeutic strategies on the survival of patients with sporadic grade 1/2, stage IV, non-functioning pNETs. Three hundred and twelve consecutive patients diagnosed between 1993 and 2010 were included. The median overall survival (OS) was 6.6 years and survival at 5 and 10 years was 62 and 34% respectively. On univariate analysis, Eastern Cooperative Oncology Group (ECOG) status > 2, grade 2, bilobar hepatic metastases, synchronous metastases, and high chromogranin A, alkalinephosphatase and lactic-dehydrogenase were associated with a significant reduction of OS. Palliative/curative surgery and loco-regional hepatic interventions were significant factors improving OS. On multivariate analysis, ECOG status >= 2, synchronous metastases, Ki-67 >= 10%, and high alkalinephosphatase correlated significantly with an increased risk of death. Both palliative/curative surgery and loco-regional hepatic interventions had a positive impact on OS. Although most parameters did not prove to be independent OS predictors at multivariate analysis, they showed a tendency towards that. Future prospective studies including larger patient populations may give greater clarity. We believe the integration of these parameters has the potential to provide a reliable prognostic score for the stratification of patients with sporadic well-differentiated metastatic non-functioning pNETs.
en
dc.subject
Cohort study
en
dc.subject
Multivariate analysis
en
dc.subject
Overall survival
en
dc.subject
Pancreatic neuroendocrine tumours
en
dc.subject
Prognostic factors
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Identifying Prognostic Factors for Well-Differentiated Metastatic Pancreatic Neuroendocrine Tumours: A Retrospective International Multicentre Cohort Study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.1159/000492223
dcterms.bibliographicCitation.journaltitle
Neuroendocrinology
dcterms.bibliographicCitation.number
4
dcterms.bibliographicCitation.originalpublishername
Karger
dcterms.bibliographicCitation.pagestart
315
dcterms.bibliographicCitation.pageend
323
dcterms.bibliographicCitation.volume
107
dcterms.rightsHolder.note
Copyright applies in this work.
dcterms.rightsHolder.url
http://rightsstatements.org/vocab/InC/1.0/
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.note.author
Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
de
refubium.note.author
This publication is shared with permission of the rights owner and made freely accessible through a DFG (German Research Foundation) funded license at either an alliance or national level.
en
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30025389
dcterms.isPartOf.issn
0028-3835
dcterms.isPartOf.eissn
1423-0194