dc.contributor.author
Schleifenbaum, Johanna
dc.date.accessioned
2019-08-13T08:49:58Z
dc.date.available
2019-08-13T08:49:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/25269
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-3975
dc.description.abstract
Only a few years ago, alamandine was found to be a member of the protective arm of the renin-angiotensin system. It turned out to be an endogenous ligand of the G protein-coupled receptor MrgD. So far, MrgD had predominantly been studied in a neuronal context. The expression of the receptor in non-neuronal tissue showed hitherto unknown effects mediated by MrgD, most strikingly alamandine-induced vasodilation. Alamandine being a part of the non-classical renin-angiotensin system, a protective role of receptor activation seemed natural. This review summarizes the different effects of MrgD activation by alamandine in vasculature, in the central nervous system, and in organs as kidney and heart. Alamandine and MrgD are promising novel drug targets to protect the kidney and heart through anti-hypertensive actions.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
renin-angiotensin system
en
dc.subject
hypertension
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Alamandine and Its Receptor MrgD Pair Up to Join the Protective Arm of the Renin-Angiotensin System
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
107
dcterms.bibliographicCitation.doi
10.3389/fmed.2019.00107
dcterms.bibliographicCitation.journaltitle
Frontiers in Medicine
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
6
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31245374
dcterms.isPartOf.eissn
2296-858X
