dc.contributor.author
Boeth, Heide
dc.contributor.author
Raffalt, Peter C.
dc.contributor.author
MacMahon, Aoife
dc.contributor.author
Poole, A. Robin
dc.contributor.author
Eckstein, Felix
dc.contributor.author
Wirth, Wolfgang
dc.contributor.author
Buttgereit, Frank
dc.contributor.author
Önnerfjord, Patrik
dc.contributor.author
Lorenzo, Pilar
dc.contributor.author
Klint, Cecilia
dc.contributor.author
Pramhed, Anna
dc.contributor.author
Duda, Georg N.
dc.date.accessioned
2019-06-25T13:45:14Z
dc.date.available
2019-06-25T13:45:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24927
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2687
dc.description.abstract
Background: An early detection of Osteoarthritis is urgently needed and still not possible until today. The aim of
the study was to assess whether molecular biomarkers of cartilage turnover are associated with longitudinal change
in knee cartilage thickness during a 2 year period in individuals with increased risk of developing knee
osteoarthritis. A secondary aim was to assess whether prior knee injury or subjective patient-reported outcomes at
baseline (BL) were associated with articular cartilage changes. Nineteen volleyball players (mean age 46.5 ± 4.9 years,
47% male) with a 30-year history of regular high impact training were recruited. The serum biomarkers Cpropeptide
of type II procollagen (CPII), cartilage oligomeric matrix protein (COMP), collagenase generated carboxy-terminal
neoepitope of type II collagen (sC2C), cartilage intermediate layer protein 2 (CILP-2), and the urine biomarkers Ctelopeptide
of type II collagen (CTX-II) and collagenase-generated peptide(s) of type II collagen (C2C-HUSA) were
assessed at BL and at 2 year follow up (FU). Femorotibial cartilage thinning, thickening and absolute thickness
change between BL and FU was evaluated from magnetic resonance imaging. Subjective clinical status at BL was
evaluated by the International Knee Documentation Committee Subjective Knee Form and the Short-Form 36
Physical Component Score.
Results: CILP-2 was significantly higher at FU and linearly associated with the absolute cartilage thickness change
during the experimental period. Prior injury was a predictor of increased absolute cartilage thickness change.
Conclusion: Measuring the change in the cartilage biomarker CILP-2 might be a valid and sensitive method to
detect early development of knee osteoarthritis as CILP-2 appears to be related to cartilage thickness loss in certain
individuals with increased risk of developing knee osteoarthritis. Prior knee injury may be predictive of increased
articular cartilage thickness change.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Cartilage degradation
en
dc.subject
Knee osteoarthritis
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
19
dcterms.bibliographicCitation.doi
10.1186/s40634-019-0179-3
dcterms.bibliographicCitation.journaltitle
Journal of Experimental Orthopaedics
dcterms.bibliographicCitation.originalpublishername
SpringerOpen
dcterms.bibliographicCitation.volume
6
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31053993
dcterms.isPartOf.eissn
2197-1153