dc.contributor.author
Malinka, Thomas
dc.contributor.author
Nebrig, Maxim
dc.contributor.author
Klein, Fritz
dc.contributor.author
Pratschke, Johann
dc.contributor.author
Bahra, Marcus
dc.contributor.author
Andreou, Andreas
dc.date.accessioned
2019-06-17T11:02:59Z
dc.date.available
2019-06-17T11:02:59Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24767
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2527
dc.description.abstract
Background:
Retroperitoneal sarcomas (RPS) include a heterogeneous group of rare malignant tumours, and various treatment algorithms are still controversially discussed until today. The present study aimed to examine postoperative and long-term outcomes after resection of primary RPS.
Patients and methods:
Clinicopathological data of patients who underwent resection of primary RPS between 2005 and 2015 were assessed, and predictors for overall survival (OS) and disease-free survival (DFS) were identified.
Results:
Sixty-one patients underwent resection for primary RPS. Postoperative morbidity and mortality rates were 31 and 3%, respectively. After a median follow-up time of 74 months, 5-year OS and DFS rates were 58 and 34%, respectively. Histologic high grade (5-year OS: G1: 92% vs. G2: 54% vs. G3: 43%, P = 0.030) was significantly associated with diminished OS in univariate and multivariate analyses. When assessing DFS, histologic high grade (5-year DFS: G1: 63% vs. G2: 24% vs. G3: 22%, P = 0.013), positive surgical resection margins (5-year DFS: R0: 53% vs. R1: 10% vs. R2: 0%, P = 0.014), and vascular involvement (5-year DFS: yes: 33% vs no: 39%, P = 0.001), were significantly associated with inferior DFS in univariate and multivariate analyses.
Conclusions:
High-grade tumours indicated poor OS, while vascular involvement, positive surgical resection margins, and histologic grade are the most important predictors of DFS. Although multimodal treatment strategies are progressively established, surgical resection remains the mainstay in the majority of patients with RPS, even in cases with vascular involvement.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
Retroperitoneal sarcoma
en
dc.subject
Overall survival
en
dc.subject
Disease-free survival
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Analysis of outcomes and predictors of long-term survival following resection for retroperitoneal sarcoma
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
61
dcterms.bibliographicCitation.doi
10.1186/s12893-019-0521-9
dcterms.bibliographicCitation.journaltitle
BMC Surgery
dcterms.bibliographicCitation.originalpublishername
BMC
dcterms.bibliographicCitation.volume
19
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31182086
dcterms.isPartOf.eissn
1471-2482