dc.contributor.author
Aurich, Stefanie
dc.contributor.author
Dölle-Bierke, Sabine
dc.contributor.author
Francuzik, Wojciech
dc.contributor.author
Bilo, Maria Beatrice
dc.contributor.author
Christoff, George
dc.contributor.author
Fernandez-Rivas, Montserrat
dc.contributor.author
Hawranek, Thomas
dc.contributor.author
Pföhler, Claudia
dc.contributor.author
Poziomkowska-Gȩsicka, Iwona
dc.contributor.author
Renaudin, Jean-Marie
dc.contributor.author
Oppel, Eva
dc.contributor.author
Scherer, Kathrin
dc.contributor.author
Treudler, Regina
dc.contributor.author
Worm, Margitta
dc.date.accessioned
2019-06-06T07:27:58Z
dc.date.available
2019-06-06T07:27:58Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24683
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2443
dc.description.abstract
Background: Elicitors and symptoms of anaphylaxis are age dependent. However, little is known about typical features of anaphylaxis in patients aged 65 years or more. Methods: The data from the Network for Online Registration of Anaphylaxis (NORA) considering patients aged >= 65 (elderly) in comparison to data from adults (18-64 years) regarding elicitors, symptoms, comorbidities, and treatment measures were analyzed. Results: We identified 1,123 elderly anaphylactic patients. Insect venoms were the most frequent elicitor in this group (p < 0.001), followed by drugs like analgesics and antibiotics. Food allergens elicited less frequently anaphylaxis (p < 0.001). Skin symptoms occurred less frequently in elderly patients (77%, p < 0.001). The clinical symptoms were more severe in the elderly (51% experiencing grade III/IV reactions), in particular when skin symptoms (p < 0.001) were absent. Most strikingly, a loss of consciousness (33%, p < 0.001) and preexisting cardiovascular comorbidity (59%, p < 0.001) were more prevalent in the elderly. Finally, adrenaline was used in 30% of the elderly (vs. 26% in the comparator group, p < 0.001) and hospitalization was more often required (60 vs. 50%, p < 0.001). Discussion and Conclusion: Anaphylaxis in the elderly is often caused by insect venoms and drugs. These patients suffer more often from cardiovascular symptoms, receive more frequently adrenaline and require more often hospitalization. The data indicate that anaphylaxis in the elderly tends to be more frequently life threatening and patients require intensified medical intervention. The data support the need to recognize anaphylaxis in this patient group, which is prone to be at a higher risk for a fatal outcome.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject
insect venom
en
dc.subject
drug hypersensitivity
en
dc.subject
hospitalization
en
dc.subject
loss of consciousness
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
Anaphylaxis in Elderly Patients—Data From the European Anaphylaxis Registry
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
750
dcterms.bibliographicCitation.doi
10.3389/fimmu.2019.00750
dcterms.bibliographicCitation.journaltitle
Frontiers in Immunology
dcterms.bibliographicCitation.originalpublishername
Frontiers Media S.A.
dcterms.bibliographicCitation.volume
10
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
31068925
dcterms.isPartOf.issn
1664-3224