dc.contributor.author
Atanasov, Georgi
dc.contributor.author
Pötner, Charlotte
dc.contributor.author
Aust, Gabriela
dc.contributor.author
Schierle, Katrin
dc.contributor.author
Dietel, Corinna
dc.contributor.author
Benzing, Christian
dc.contributor.author
Krenzien, Felix
dc.contributor.author
Bartels, Michael
dc.contributor.author
Eichfeld, Uwe
dc.contributor.author
Schmelzle, Moritz
dc.contributor.author
Bahra, Marcus
dc.contributor.author
Pascher, Andreas
dc.contributor.author
Wiltberger, Georg
dc.date.accessioned
2019-05-16T15:06:14Z
dc.date.available
2019-05-16T15:06:14Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24584
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2347
dc.description.abstract
Introduction: M2-polarized tumor-associated macrophages (TAMs) and TIE2- expressing monocytes (TEMs) are associated with angiogenesis and have been identified as a potential prognostic marker in several solid tumors, including hepatobiliary malignancies. However, little is known regarding their influence on tumor progression and patient survival in pancreatic ductal adenocarcinoma (PDAC).
Results: Patients with tumors characterized by the presence of CD163+ TAMs or TEMs in TCA or TIF, respectively, showed a significantly decreased 1-, 3- and 5-year overall and recurrence-free survival compared to patients without CD163+ TAMs or TEMs (all ρ < 0.05). Patients with TEMs in TCA showed a higher incidence of tumor recurrence (ρ < 0.05). Furthermore, the presence of CD163+ TAMs was associated with a higher tumor MVD (ρ < 0.05).
Conclusions: Presence of M2-polarized TAMs and TEMs is associated with a decreased overall and recurrence-free survival of patients with PDAC.
Materials and methods: The localization and density of CD163+ M2-polarized TAMs and TEMs were quantified in the tumor central area (TCA) and tumor-infiltrating front (TIF) in human PDAC tissue (n = 106) and correlated to clinicopathological characteristics, tumor recurrence rates and patient survival. In parallel, tumor microvascular density (MVD) and the density of angiopoietin-positive tumor cells were quantified. Statistical analysis was performed using SPSS software.
en
dc.rights.uri
https://creativecommons.org/licenses/by/3.0/
dc.subject
TIE2-expressing monocytes
en
dc.subject
pancreatic adenocarcinoma
en
dc.subject
tumor-associated macrophages
en
dc.subject
M2-macrophages
en
dc.subject
angiogenesis
en
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
TIE2-expressing monocytes and M2-polarized macrophages impact survival and correlate with angiogenesis in adenocarcinoma of the pancreas
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.doi
10.18632/oncotarget.25690
dcterms.bibliographicCitation.journaltitle
Oncotarget
dcterms.bibliographicCitation.number
51
dcterms.bibliographicCitation.originalpublishername
Impact Journals LLC
dcterms.bibliographicCitation.pagestart
29715
dcterms.bibliographicCitation.pageend
29726
dcterms.bibliographicCitation.volume
9
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30038715
dcterms.isPartOf.issn
1949-2553