dc.contributor.author
Zeeuw, Jan de
dc.contributor.author
Wisniewski, Sophia
dc.contributor.author
Papakonstantinou, Alexandra
dc.contributor.author
Bes, Frederik
dc.contributor.author
Wahnschaffe, Amely
dc.contributor.author
Zaleska, Mandy
dc.contributor.author
Kunz, Dieter
dc.contributor.author
Münch, Mirjam
dc.date.accessioned
2019-04-10T12:23:28Z
dc.date.available
2019-04-10T12:23:28Z
dc.identifier.uri
https://refubium.fu-berlin.de/handle/fub188/24357
dc.identifier.uri
http://dx.doi.org/10.17169/refubium-2129
dc.description.abstract
Under entrained conditions, the accumulation of homeostatic sleep pressure in the evening is opposed by a strong circadian arousal signal prior to the dim light melatonin onset, called the Wake Maintenance Zone (WMZ). This study aimed at investigating the impact of the WMZ on different cognitive performance tests, as well as on subjective and objective sleepiness. Twelve young male participants completed a constant routine protocol with 40 h of extended wakefulness that included two WMZs. Cognitive tests and saliva samples were assessed hourly, while the electroencephalogram (EEG) was recorded continuously. Participants improved in cognitive response inhibition during WMZ1 (13.5 h awake) and sustained attention during WMZ2 (37.5 h awake), but not in higher executive function tests. There were significant EEG power density reductions in the delta/theta frequency range during WMZ1 and in delta/theta, alpha, and sigma/beta ranges during WMZ2, with a greater change in the sigma/beta range during WMZ2 compared toWMZ1. EEG power reductions coincided during WMZ1 with stable subjective sleepiness and sustained attention. During WMZ2, EEG power reductions were more pronounced and coincided with improved sustained attention. Our results suggest the circadian arousal signal in the evening differently modulates cognitive functions and EEG power depending on the duration of prior wakefulness.
en
dc.rights.uri
https://creativecommons.org/licenses/by/4.0/
dc.subject.ddc
600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.title
The alerting effect of the wake maintenance zone during 40 hours of sleep deprivation
dc.type
Wissenschaftlicher Artikel
dcterms.bibliographicCitation.articlenumber
11012
dcterms.bibliographicCitation.doi
10.1038/s41598-018-29380-z
dcterms.bibliographicCitation.journaltitle
Scientific Reports
dcterms.bibliographicCitation.originalpublishername
Nature Publishing Group
dcterms.bibliographicCitation.volume
8
refubium.affiliation
Charité - Universitätsmedizin Berlin
refubium.resourceType.isindependentpub
no
dcterms.accessRights.openaire
open access
dcterms.bibliographicCitation.pmid
30030487
dcterms.isPartOf.issn
2045-2322